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Titolo:
Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis
Autore:
Adrie, C; Bachelet, M; Vayssier-Taussat, M; Russo-Marie, F; Bouchaert, I; Adib-Conquy, M; Cavaillon, JM; Pinsky, MR; Dhainaut, JF; Polla, BS;
Indirizzi:
Univ Pittsburgh, Div Crit Care Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Div Crit Care Med, Pittsburgh, PA USA Inst Pasteur, Immunoallergy Unit, Paris, France Inst Pasteur Paris France st Pasteur, Immunoallergy Unit, Paris, France Cochin Port Royal Hosp, INSERM U332, APHP, Med Intens Care Unit,ICGM, Paris, France Cochin Port Royal Hosp Paris France ntens Care Unit,ICGM, Paris, France Cochin Port Royal Hosp, INSERM U332, APHP, ICGM,Lab Resp Physiol, Paris, France Cochin Port Royal Hosp Paris France CGM,Lab Resp Physiol, Paris, France
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 389 - 395
SICI:
1073-449X(20010801)164:3<389:MMPAAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK RESPONSE; CELL-DEATH; ORGAN DYSFUNCTION; IMPROVES SURVIVAL; ENDOTOXIN-SHOCK; PROTECTS RATS; BCL-2; MICE; EXPRESSION; MECHANISMS;
Keywords:
mitochondria; apoptosis; sepsis; heat-shock protein 70; proto-oncogene protein c-Bcl-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Adrie, C CHU Cochin Port Royal, Serv Reanimat Med, 27 Rue Faubourg St Jacques, F-75679 Paris 14, France CHU Cochin Port Royal 27 Rue Faubourg St Jacques Paris France 14
Citazione:
C. Adrie et al., "Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis", AM J R CRIT, 164(3), 2001, pp. 389-395

Abstract

Reduced mitochondrial membrane potential (Delta psim), which is consideredas an initial and irreversible step towards apoptosis, as well as cell death regulating proteins, such as Fas, Hsp70, or Bcl-2, may play an importantrole in sepsis. We studied the relationship between sepsis severity and peripheral blood monocyte Delta psim, cell death (necrosis and apoptosis), soluble Fas ligand, Hsp70, and Bcl-2 expression over time in 18 patients withsepsis, and compared these data with those of a group of 17 healthy control subjects. All measurements were performed within 3 d of the onset of severe sepsis (T1), then 7 to 10 d later (T2), and finally at hospital discharge (T3). Delta psim was expressed as the percent monocytes with altered Delta psim (%Delta psim). Patients with sepsis had greater %Delta psim at T1 and T2 but not at T3 (14.6 +/- 2.6% and 15.9 +/- 2%, respectively, versus control 6.6 +/- 0.2%, p < 0.01). Septic patients exhibited greater cell death in their monocytes and had greater Hsp70 expression only at T1. Bcl-2 levels were similar in septic and control subjects. Comparing survivors with non-survivors of sepsis, nonsurvivors had a greater %Delta psim at T1 (26.4 +/- 5.3% versus 10.1 +/- 2.7%, p < 0.01) and a significant decrease in Bcl-2 expression, whereas no difference was found in Hsp70 levels. These results indicate that mitochondrial dysfunction and subsequent cell death occur in severe sepsis and suggest that %Delta psim is a marker of severity in humansepsis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:29:28