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Titolo:
Validity and safety of sputum induction by inhaled uridine 5 '-triphosphate
Autore:
Tamaoki, J; Kondo, M; Kuroda, H; Aoshiba, K; Takeyama, K; Nakata, J; Nagai, A;
Indirizzi:
Tokyo Womens Med Univ, Sch Med, Dept Med 1, Shinjuku Ku, Tokyo 162, Japan Tokyo Womens Med Univ Tokyo Japan 162 d 1, Shinjuku Ku, Tokyo 162, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 378 - 381
SICI:
1073-449X(20010801)164:3<378:VASOSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTIC-FIBROSIS; EXTRACELLULAR NUCLEOTIDES; MUCOCILIARY CLEARANCE; AIRWAY INFLAMMATION; HEALTHY-SUBJECTS; CELLS; CHALLENGE; SECRETION; ASTHMA; ADULTS;
Keywords:
uridine triphosphate; induced sputum; airway inflammation; bronchoconstriction; asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nagai, A Tokyo Womens Med Univ, Sch Med, Dept Med 1, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 162, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 162 162, Japan
Citazione:
J. Tamaoki et al., "Validity and safety of sputum induction by inhaled uridine 5 '-triphosphate", AM J R CRIT, 164(3), 2001, pp. 378-381

Abstract

Inhalation of hypertonic saline during sputum induction causes bronchoconstriction. We studied the validity and safety of sputum induction by uricline 5 ' -triphosphate (UTP). Sputum was induced by a 5-min inhalation of hypertonic saline (3%) on Day 1 and UTP (5 mg/ml in 0.9% saline) on Days 8 and 15 in 16 healthy subjects and 16 patients with mild-to-moderate asthma. Inhaled UTP produced twofold greater amounts of sputum than did hypertonic saline. There were significant differences in oxygen desaturation and bronchoconstriction during the procedure between the two methods: the maximal fall in Sa(O2), the AUC of the Sa(O2)-time response, and the fall in PEF were less in the subjects who received UTP than in those who received hypertonic saline. Sputum total cell and differential cell counts, with a high proportion of eosinophils in asthmatics, were similar between specimens obtained byhypertonic saline and UTP. When we compared two consecutive measurements on the UTP-induced sputum samples, the reproducibility calculated by the intraclass correlation coefficient was high for the proportion of eosinophils,neutrophils, and macrophages. Therefore, inhalation of UTP aerosols may provide an effective, relatively noninvasive, valid, and reproducible method of sputum induction for the assessment of airway inflammation in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:20:49