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Titolo:
Amplification of inflammation in emphysema and its association with latentadenoviral infection
Autore:
Retamales, I; Elliott, WM; Meshi, B; Coxson, HO; Pare, PD; Sciurba, FC; Rogers, RM; Hayashi, S; Hogg, JC;
Indirizzi:
Univ British Columbia, McDonald Res Labs, St Pauls Hosp, Vancouver, BC V6Z1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 uver, BC V6Z1Y6, Canada Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Med Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Care Med, Med Ctr, Pittsburgh, PA USA Univ Pittsburgh, Sch Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ittsburgh, Sch Med, Pittsburgh, PA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 469 - 473
SICI:
1073-449X(20010801)164:3<469:AOIIEA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PERIPHERAL AIRWAYS; COMPUTED-TOMOGRAPHY; CIGARETTE-SMOKING; EPITHELIAL-CELLS; DNA-SEQUENCES; E1A PROTEINS; HUMAN-LUNG; SMOKERS; QUANTIFICATION;
Keywords:
emphysema; lung inflammation; latent adenoviral infection; cigarette smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hogg, JC Univ British Columbia, McDonald Res Labs, St Pauls Hosp, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia 1081 Burrard St Vancouver BC Canada V6Z 1Y6
Citazione:
I. Retamales et al., "Amplification of inflammation in emphysema and its association with latentadenoviral infection", AM J R CRIT, 164(3), 2001, pp. 469-473

Abstract

This study examines the hypothesis that the cigarette smoke-induced inflammatory process is amplified in severe emphysema and explores the association of this response with latent adenoviral infection. Lung tissue from patients with similar smoking histories and either no (n = 7), mild (n = 7), or severe emphysema (n = 7) was obtained by lung resection. Numbers of polymorphonuclear cells (PMN), macrophages, B cells, CD4, CD8 lymphocytes, and eosinophils present in tissue and airspaces and of epithelial cells expressingadenoviral E1A protein were determined using quantitative techniques. Severe emphysema was associated with an absolute increase in the total number of inflammatory cells in the lung tissue and airspaces. The computed tomography (CT) determined extent of lung destruction was related to the number ofcells/m(2) surface area by R-2 values that ranged from 0.858 (CD8 cells) to 0.483 (B cells) in the tissue and 0.630 (CD4 cells) to 0.198 (B cells) inthe airspaces. These changes were associated with a 5- to 40-fold increasein the number of alveolar epithelial cells expressing adenoviral EIA protein in mild and severe disease, respectively. We conclude that cigarette smoke-induced lung inflammation is amplified in severe emphysema and that latent expression of the adenoviral E1A protein expressed by alveolar epithelial cells influenced this amplification process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:45:18