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Titolo:
Temperature-sensitive properties of rat suprachiasmatic nucleus neurons
Autore:
Burgoon, PW; Boulant, JA;
Indirizzi:
Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 & Cell Biol, Columbus, OH 43210 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: R706 - R715
SICI:
0363-6119(200109)281:3<R706:TPORSN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR MECHANISMS; HYPOTHALAMIC SLICES; VOLTAGE CLAMP; IN-VITRO; THERMOSENSITIVITY; COMPENSATION;
Keywords:
circadian rhythms; threshold; intracellular recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Boulant, JA Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, 1645 NeilAve, Columbus, OH 43210 USA Ohio State Univ 1645 Neil Ave Columbus OH USA 43210 43210 USA
Citazione:
P.W. Burgoon e J.A. Boulant, "Temperature-sensitive properties of rat suprachiasmatic nucleus neurons", AM J P-REG, 281(3), 2001, pp. R706-R715

Abstract

The hypothalamic suprachiasmatic, nucleus (SCN) contains a heterogeneous population of neurons, some of which are temperature sensitive in their Bring rate activity. Neuronal thermosensitivity may provide cues that synchronize the circadian clock. In addition, through synaptic inhibition on nearby cells, thermosensitive neurons may provide temperature compensation to other SCN neurons, enabling postsynaptic neurons to maintain a constant firing rate despite changes in temperature. To identify mechanisms of neuronal thermosensitivity, whole cell patch recordings monitored resting and transientpotentials of SCN neurons in rat hypothalamic tissue slices during changesin temperature. Firing rate temperature sensitivity is not due to thermally dependent changes in the resting membrane potential, action potential threshold, or amplitude of the fast afterhyperpolarizing potential (AHP). The primary mechanism of neuronal thermosensitivity resides in the depolarizingprepotential, which is the slow depolarization that occurs prior to the membrane potential reaching threshold. In thermosensitive neurons, warming increases the prepotential's rate of depolarization, such that threshold is reached sooner. This shortens the interspike interval and increases the firing rate. In some SCN neurons, the slow component of the AHP provides an additional mechanism for thermosensitivity. In these neurons, warming causes the slow AHP to begin at a more depolarized level, and this, in turn, shortens the interspike interval to increase firing rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:42:27