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Titolo:
Altered hormone levels and circadian rhythm of activity in the WKY rat, a putative animal model of depression
Autore:
Solberg, LC; Olson, SL; Turek, FW; Redei, E;
Indirizzi:
Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Behav Sci, Chicago, IL 60611 USA Northwestern Univ, Dept Neurobiol & Physiol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 l & Physiol, Chicago, IL 60611 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: R786 - R794
SICI:
0363-6119(200109)281:3<R786:AHLACR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; FORCED SWIMMING TEST; WISTAR-KYOTO RATS; SPONTANEOUSLY HYPERTENSIVE RATS; PITUITARY-ADRENAL ACTIVITY; CHRONIC MILD STRESS; OPEN-FIELD BEHAVIOR; FREE-RUNNING PERIOD; THYROID-HORMONE; STRAIN DIFFERENCES;
Keywords:
hypothalamic-pituitary-adrenal axis; hypothalamic-pituitary-thyroid axis; forced swim test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Solberg, LC Northwestern Univ, Dept Psychiat & Behav Sci, 303 E Chicago Ave,Ward 9-246, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave,Ward 9-246 Chicago IL USA 60611
Citazione:
L.C. Solberg et al., "Altered hormone levels and circadian rhythm of activity in the WKY rat, a putative animal model of depression", AM J P-REG, 281(3), 2001, pp. R786-R794

Abstract

The Wistar Kyoto (WKY) rat is hyperreactive to stress and exhibits depressive-like behavior in several standard behavioral tests. Because patients with depressive disorders often exhibit disruptions in the circadian rhythm of activity, as well as altered secretory patterns of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid hormones, we tested the hypothesis that these phenomena occur in the WKY rat. Plasma ACTH and corticosterone levels remained significantly higher after the diurnal peak for several hours in WKY rats relative to Wistar rats. Also, plasma levels of thyroid-stimulating hormone were significantly higher in WKY relative to Wistar rats across the 24-h period, despite normal or slightly higher levels of 3,5,3'-triiodothyronine. In addition, under constant darkness conditions, WKYrats exhibited a shorter free running period and a decreased response to aphase-delaying light pulse compared with Wistar rats. In several ways these results are similar to those seen in other animal models of depression aswell as in depressed humans, suggesting that the WKY rat could be used to investigate the genetic basis for these abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:28:57