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Titolo:
Mineralocorticoids upregulate arterial contraction to epidermal growth factor
Autore:
Florian, JA; Dorrance, A; Webb, RC; Watts, SW;
Indirizzi:
Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 xicol, E Lansing, MI 48824 USA Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Dept Physiol, Augusta, GA 30912 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: R878 - R886
SICI:
0363-6119(200109)281:3<R878:MUACTE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; SPONTANEOUSLY HYPERTENSIVE RATS; EGF RECEPTOR; ANGIOTENSIN-II; MESSENGER-RNA; ALDOSTERONE; EXPRESSION; STIMULATION; INDUCTION;
Keywords:
hypertension; vascular smooth muscle contraction; Wistar/Wistar-Furth rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Watts, SW Michigan State Univ, Dept Pharmacol & Toxicol, B445 Life Sci Bldg, E Lansing, MI 48824 USA Michigan State Univ B445 Life Sci Bldg E LansingMI USA 48824 SA
Citazione:
J.A. Florian et al., "Mineralocorticoids upregulate arterial contraction to epidermal growth factor", AM J P-REG, 281(3), 2001, pp. R878-R886

Abstract

The present studies test the hypothesis that contraction to EGF is dependent on mineralocorticoids and/or an elevation in systolic blood pressure (SBP). Endothelium-denuded thoracic aortas from sham normotensive, N-omega-nitro-L-arginine (L-NNA) hypertensive, Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR) were used in isolated tissue-bath experiments. Maximal contraction to epidermal growth factor [EGF; percentage of phenylephrine(PE; 10 umol/l)-induced contraction] was greater in strips from L-NNA (32 /-5%) and SHR (53 +/-8%) rats compared with sham and WKY rats (17 +/-1 and12 +/-4%, respectively). Wistar-Furth rats became only mildly hypertensivewhen given DOCA salt (134 +/-6 mmHg) compared with Wistar rats (176 +/-9 mmHg), but aortas from both strains had a similarly enhanced contraction to EGF (similar to9 times the maximal contraction of sham aorta). Furthermore,in vitro incubation of aortas from Wistar and Wistar-Furth rats with aldosterone (10 nmol/l) increased EGF-receptor mRNA expression by >50%. These data indicate that arterial contraction to EGF may occur independent of hypertension and be stimulated by mineralocorticoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:30:22