Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence that hemorrhagic hypotension is mediated by the ventrolateral periaqueductal gray region
Autore:
Cavun, S; Millington, WR;
Indirizzi:
Albany Coll Pharm, Dept Basic & Pharmaceut Sci, Albany, NY 12208 USA Albany Coll Pharm Albany NY USA 12208 harmaceut Sci, Albany, NY 12208 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: R747 - R752
SICI:
0363-6119(200109)281:3<R747:ETHHIM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM; CONSCIOUS RABBITS; ARTERIAL-PRESSURE; CENTRAL PATHWAYS; FOS EXPRESSION; RAT; MIDBRAIN; PROJECTIONS; MEDULLA; NEURONS;
Keywords:
hemorrhage; cardiovascular regulation; lidocaine; cobalt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Millington, WR Albany Coll Pharm, Dept Basic & Pharmaceut Sci, 106 New Scotland Ave, Albany, NY 12208 USA Albany Coll Pharm 106 New Scotland Ave Albany NY USA 12208
Citazione:
S. Cavun e W.R. Millington, "Evidence that hemorrhagic hypotension is mediated by the ventrolateral periaqueductal gray region", AM J P-REG, 281(3), 2001, pp. R747-R752

Abstract

Severe hemorrhage lowers arterial pressure by suppressing sympathetic activity. This study tested the hypothesis that the decompensatory phase of hemorrhage is mediated by the ventrolateral periaqueductal gray (vlPAG), a region importantly involved in the autonomic and behavioral responses to stress and trauma. Neuronal activity in the vlPAG was inhibited with either lidocaine or cobalt chloride 5 min before hemorrhage (2.5 ml/100 g body wt) wasinitiated in conscious, unrestrained rats. Bilateral injection of lidocaine (0.5 mul of a 2% or 1 mul of a 5% solution) into the caudal vlPAG delayedthe onset and reduced the magnitude of the hypotension produced by hemorrhage significantly. In contrast, inactivation of the dorsolateral PAG with lidocaine was ineffective. Cobalt chloride (5 mM; 0.5 mul), which inhibits synaptic transmission but not axonal conductance, also attenuated hemorrhagic hypotension significantly. Microinjection of lidocaine or cobalt chlorideinto the vlPAG of normotensive, nonhemorrhaged rats did not influence cardiovascular function. These data indicate that the vlPAG plays an important role in the response to hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:49:43