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Titolo:
Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt
Autore:
Fu, Q; Iwase, S; Niimi, Y; Kamiya, A; Kawanokuchi, J; Cui, J; Mano, T; Suzumura, A;
Indirizzi:
Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: R778 - R785
SICI:
0363-6119(200109)281:3<R778:EOLBPP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-RESPONSES; NEGATIVE-PRESSURE; NEURAL ACTIVITY; HUMANS; REFLEX; BAROREFLEX; TROUSERS; EXERCISE; SHOCK; NOREPINEPHRINE;
Keywords:
cardiopulmonary baroreceptors; arterial baroreceptors; intramuscular pressure-sensitive receptors; fluid shift;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Iwase, S Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan Nagoya Univ Furo Cho Nagoya Aichi Japan 4648601 hi 4648601, Japan
Citazione:
Q. Fu et al., "Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt", AM J P-REG, 281(3), 2001, pp. R778-R785

Abstract

The present study was performed to test the hypothesis that application oflower body positive pressure (LBPP) during orthostasis would reduce the baroreflex-mediated enhancement in sympathetic activity in humans. Eight healthy young men were exposed to a 70 degrees head-up tilt (HUT) on application of 30 mmHg LBPP. Muscle sympathetic nerve activity (MSNA) was microneurographically recorded from the tibial nerve, along with hemodynamic variables. We found that in the supine position with LBPP, MSNA remained unchanged (13.4 +/- 3.3 vs. 11.8 +/- 2.3 bursts/min, without vs. with LBPP; P > 0.05),mean arterial pressure was elevated, but arterial pulse pressure and heartrate did not alter. At 70 degrees HUT with LBPP, the enhanced MSNA response was reduced (33.8 +/- 5.0 vs. 22.5 +/- 2.2 bursts/min, without vs. with LBPP; P < 0.05), mean arterial pressure was higher, the decreased pulse pressure was restored, and the increased heart rate was attenuated. We concludethat the baroreflex-mediated enhancement in sympathetic activity during HUT was reduced by LBPP. Application of LBPP in HUT induced an obvious cephalad fluid shift as well as a restoration of arterial pulse pressure, which reduced the inhibition of the baroreceptors. However, the activation of the intramuscular mechanoreflexes produced by 30 mmHg LBPP might counteract theeffects of baroreflexes.

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Documento generato il 18/01/20 alle ore 22:20:58