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Titolo:
Intermittent hypoxia: cell to system
Autore:
Prabhakar, NR; Fields, RD; Baker, T; Fletcher, EC;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA NICHHD, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892NICHHD, NIH, Bethesda, MD 20892 USA Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 omparat Biosci, Madison, WI 53706 USA Univ Louisville, Dept Med, Div Resp Crit Care & Environm Med, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 onm Med, Louisville, KY 40292 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: L524 - L528
SICI:
1040-0605(200109)281:3<L524:IHCTS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC EPISODIC HYPOXIA; BLOOD-PRESSURE ELEVATION; DEPENDENT REGULATION; RATS;
Keywords:
protein kinases; gene expression; carotid body chemoreceptors; respiratory plasticity; blood pressure control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Prabhakar, NR Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
N.R. Prabhakar et al., "Intermittent hypoxia: cell to system", AM J P-LUNG, 281(3), 2001, pp. L524-L528

Abstract

This symposium was organized to present research dealing with the effects of intermittent hypoxia on cardiorespiratory systems and cellular mechanisms. The pattern of neural impulse activity has been shown to be critical in the induction of genes in neuronal cells and involves distinct signaling pathways. Mechanisms associated with different patterns of intermittent hypoxia might share similar mechanisms. Chronic intermittent hypoxia selectivelyaugments carotid body sensitivity to hypoxia and causes long-lasting activation of sensory discharge. Intermittent hypoxia also activates hypoxia-inducible factor-1. Reactive oxygen species are critical in altering carotid body function and hypoxia-inducible factor-1 activation caused by intermittent hypoxia. Blockade of serotonin function in the spinal cord prevents long-term facilitation in respiratory motor output elicited by episodic hypoxiaand requires de novo protein synthesis. Chronic intermittent hypoxia leadsto sustained elevation in arterial blood pressure and is associated with upregulation of catecholaminergic and renin-angiotensin systems and downregulation of nitric oxide synthases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:50:25