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Titolo:
Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions
Autore:
Hickman-Davis, JM; Fang, FC; Nathan, C; Shepherd, VL; Voelker, DR; Wright, JR;
Indirizzi:
Univ Alabama, Dept Anesthesiol, THT 940, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 l, THT 940, Birmingham, AL 35294 USA Univ Colorado, Hlth Sci Ctr, Clin Microbiol Lab, Denver, CO 80262 USA UnivColorado Denver CO USA 80262 lin Microbiol Lab, Denver, CO 80262 USA Natl Jewish Ctr Immunol & Resp Med, Dept Med, Denver, CO 80206 USA Natl Jewish Ctr Immunol & Resp Med Denver CO USA 80206 nver, CO 80206 USA Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021USA Cornell Univ New York NY USA 10021 obiol & Immunol, New York, NY 10021USA Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Dept Med, Nashville, TN 37212 USA Duke Univ, Dept Cell Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Univ, Dept Cell Biol, Durham, NC 27710 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: L517 - L523
SICI:
1040-0605(200109)281:3<L517:LSAROS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; HUMAN ALVEOLAR MACROPHAGES; NADPH PHAGOCYTE OXIDASE; A-DEFICIENT MICE; PROTEIN-A; MYCOBACTERIUM-TUBERCULOSIS; IN-VIVO; EXPERIMENTAL SALMONELLOSIS; II CELLS; PEROXYNITRITE;
Keywords:
collectins; surfactant protein A; nitric oxide; peroxynitrite; innate immunity; macrophages; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Hickman-Davis, JM Univ Alabama, Dept Anesthesiol, THT 940, 619 S 19th St, Birmingham, AL 35294 USA Univ Alabama 619 S 19th St Birmingham AL USA 352944 USA
Citazione:
J.M. Hickman-Davis et al., "Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions", AM J P-LUNG, 281(3), 2001, pp. L517-L523

Abstract

Surfactant protein (SP) A and SP-D are members of the collectin superfamily. They are widely distributed within the lung, are capable of antigen recognition, and can discern self versus nonself. SPs recognize bacteria, fungi, and viruses by binding mannose and N-acetylglucosamine residues on microbial cell walls. SP-A has been shown to stimulate the respiratory burst as well as nitric oxide synthase expression by alveolar macrophages. Although nitric oxide (NO .) is a well-recognized microbicidal product of macrophages, the mechanism(s) by which NO . contributes to host defense remains undefined. The purpose of this symposium was to present current research pertaining to the specific role of SPs and reactive oxygen-nitrogen species in innate immunity. The symposium focused on the mechanisms of NO-mediated toxicity for bacterial, human, and animal models of SP-A- and NO-mediated pathogenkilling, microbial defense mechanisms against reactive oxygen-nitrogen species, specific examples and signaling pathways involved in the SP-A-mediated killing of pulmonary pathogens, the structure and binding of SP-A and SP-D to bacterial targets, and the immunoregulatory functions of SP-A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:20:13