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Titolo:
Kinetic modeling of [F-18]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model
Autore:
Bertoldo, A; Peltoniemi, P; Oikonen, V; Knuuti, J; Nuutila, P; Cobelli, C;
Indirizzi:
Univ Padua, Dept Elect & Informat, I-35131 Padua, Italy Univ Padua PaduaItaly I-35131 pt Elect & Informat, I-35131 Padua, Italy Univ Turku, Dept Med, F-20520 Turku, Finland Univ Turku Turku Finland F-20520 Turku, Dept Med, F-20520 Turku, Finland Univ Turku, Turku PET Ctr, F-20520 Turku, Finland Univ Turku Turku Finland F-20520 , Turku PET Ctr, F-20520 Turku, Finland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 281, anno: 2001,
pagine: E524 - E536
SICI:
0193-1849(200109)281:3<E524:KMO[IS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; GLUCOSE-TRANSPORT; LUMPED CONSTANT; F-18 FLUORODEOXYGLUCOSE; INSULIN-RESISTANCE; SPECTRAL-ANALYSIS; BLOOD-FLOW; IN-VIVO; PHOSPHORYLATION; HUMANS;
Keywords:
positron emission tomography; parameter estimation; glucose; compartmental model; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Cobelli, C Univ Padua, Dept Elect & Informat, Via Gradenigo 6-A, I-35131 Padua, Italy Univ Padua Via Gradenigo 6-A Padua Italy I-35131 Padua, Italy
Citazione:
A. Bertoldo et al., "Kinetic modeling of [F-18]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model", AM J P-ENDO, 281(3), 2001, pp. E524-E536

Abstract

Various modeling strategies have been developed to convert regional [F-18]fluorodeoxyglucose ([F-18]FDG) concentration measured by positron emission tomography (PET) to a measurement of physiological parameters. However, allthe proposed models have been developed and tested mostly for brain studies. The purpose of the present study is to select the most accurate model for describing [F-18]FDG kinetics in human skeletal muscle. The database consists of basal and hyperinsulinemic-euglycemic studies performed in normal subjects. PET data were first analyzed by an input-output modeling technique(often called spectral analysis). These results provided guidelines for developing a compartmental model. A new model with four compartments and fiverate constants (5K model) emerged as the best. By accounting for plasma and extracellular and intracellular kinetics, this model allows, for the first time, PET assessment of the individual steps of [F-18] FDG kinetics in human skeletal muscle, from plasma to extracellular space to transmembrane transport into the cell to intracellular phosphorylation. Insulin is shown toaffect transport and phosphorylation but not extracellular kinetics, with the transport step becoming the main site of control. The 5K model also allows definition of the domain of validity of the classic three-compartment three- or four-rate-constant models. These models are candidates for an investigative tool to quantitatively assess insulin control on individual metabolic steps in human muscle in normal and physiopathological states.

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Documento generato il 27/01/20 alle ore 16:44:44