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Titolo:
Alterations in IRF1/IRF2 expression in acute myelogenous leukemia
Autore:
Preisler, HD; Perambakam, S; Li, B; Hsu, WT; Venugopal, P; Creech, S; Sivaraman, S; Tanaka, N;
Indirizzi:
Rush Presbyterian St Lukes Med Ctr, Rush Canc Inst, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Tata Mem Hosp, Canc Res Inst, Mumbai, India Tata Mem Hosp Mumbai IndiaTata Mem Hosp, Canc Res Inst, Mumbai, India Natl Inst Radiol Sci, Chiba 260, Japan Natl Inst Radiol Sci Chiba Japan 260 l Inst Radiol Sci, Chiba 260, Japan
Titolo Testata:
AMERICAN JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 68, anno: 2001,
pagine: 23 - 31
SICI:
0361-8609(200109)68:1<23:AIIEIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; REGULATORY FACTOR-I; TRANSCRIPTION FACTOR IRF-1; N-RAS; GROWTH-INHIBITION; CELL-GROWTH; GENES; MUTATIONS; TRANSFORMATION; APOPTOSIS;
Keywords:
IRF1; IRF2; acute leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Preisler, HD Rush Presbyterian St Lukes Med Ctr, Rush Canc Inst, 1725 W Harrison St,Suite 809, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr 1725 W Harrison St,Suite 809 Chicago IL USA 60612
Citazione:
H.D. Preisler et al., "Alterations in IRF1/IRF2 expression in acute myelogenous leukemia", AM J HEMAT, 68(1), 2001, pp. 23-31

Abstract

The interferon response genes 1 and 2 have been shown to be involved in the regulation of differentiation and proliferation of cells of the myeloid series, with the former functioning as an anti-oncogene and the latter as anoncogene. In the study described here, the levels of expression of these two genes and the ratio of their expression were compared in AML and normal marrow. The ratio of gene expression was significantly less in AML marrow cells as compared to normal marrow cells [med ratio = 1.33 vs. 2.97, P = 0.003]. While the expression ratio was unaffected by the presence or absence of either ras or fms mutations, p53 mutations were associated with higher IRF1:IRF2 expression ratios that wt p53 genes [med = 1.701 vs. 1.135, P = 0.014]. Given the functional characteristics and the competitive nature of these two genes, it is possible that leukemic transformation is associated with a fall in IRF1:IRF2 ratios. Finally, the administration of IL4 can resultin the normalization of the IRF1:IRF2 ratio in the marrow cells of some patients with AML. Am. J. Hematol. 68:23-31, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:45:19