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Titolo:
Effects of nicotine on ethanol dependence and brain damage
Autore:
Penland, S; Hoplight, B; Obernier, J; Crews, FT;
Indirizzi:
Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 macol, Chapel Hill, NC 27599 USA Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N CarolinaChapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 24, anno: 2001,
pagine: 45 - 54
SICI:
0741-8329(200105)24:1<45:EONOED>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; NEURONAL DEGENERATION; INDUCED CYTOTOXICITY; CORTICAL-NEURONS; EMERGENCY ROOM; BLOOD-ALCOHOL; RATS; NEUROTOXICITY; WITHDRAWAL; EXPOSURE;
Keywords:
alcohol; nicotine; neurodegeneration; dependence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Crews, FT Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 pel Hill, NC 27599 USA
Citazione:
S. Penland et al., "Effects of nicotine on ethanol dependence and brain damage", ALCOHOL, 24(1), 2001, pp. 45-54

Abstract

Almost all alcoholics (80%-95%) smoke tobacco. When alcoholics binge, theyachieve high, sustained blood alcohol levels, become physically dependent,and often suffer loss of cognition and other higher cortical functions. Nicotine could have a modulatory effect on ethanol drinking behavior and ethanol-induced brain damage through its cholinergic actions. To determine whether nicotine altered alcohol dependence, alcohol-induced brain damage, or both, a rat model of binge drinking was used to study the effects of nicotine on the alcohol withdrawal syndrome and its associated brain damage. Afteradministration of the last dose of ethanol in a 4-day binge model. rats remained intoxicated for approximately 5 h, slowly returned to a neutral state, and entered a hyperexcited period, which peaked around 24 h and lasted atotal of 60 h. Behavioral signs of withdrawal included splayed limbs, tremors, and seizures. Continuous transdermal nicotine did not alter the duration or severity of ethanol withdrawal, The 4-day binge ethanol treatment caused considerable brain damage in the perirhinal cortex, entorhinal cortex, ventral dentate gyrus, and olfactory bulb as visualized with amino cupric silver stain. Nicotine alone caused little or no brain damage and did not markedly alter binge ethanol-induced damage in cortical or hippocampal regions. In the olfactory bulb. nicotine reduced ethanol-induced brain damage. Although results of other studies seem to indicate that nicotine increases alcohol consumption, our findings indicate that nicotine does not markedly change the development of alcohol dependence or alcohol-induced cortical damage. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:58:00