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Titolo:
Ethanol-induced conditioned taste aversion in the rat: effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus
Autore:
Piasecki, J; Bienkowski, P; Dudek, K; Koros, E; Kostowski, W;
Indirizzi:
Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Warsaw Poland PL-02957 t, PL-02957 Warsaw, Poland Warsaw Med Univ, Dept Surg, PL-02971 Warsaw, Poland Warsaw Med Univ Warsaw Poland PL-02971 ept Surg, PL-02971 Warsaw, Poland Warsaw Med Univ, Dept Expt & Clin Pharmacol, PL-00572 Warsaw, Poland Warsaw Med Univ Warsaw Poland PL-00572 harmacol, PL-00572 Warsaw, Poland
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 24, anno: 2001,
pagine: 9 - 14
SICI:
0741-8329(200105)24:1<9:ECTAIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING RATS; MEDIAN-RAPHE; RECEPTOR AGONISTS; SEROTONERGIC INNERVATION; 5-HT; 8-OH-DPAT; PREFERENCE; FOREBRAIN; ACCUMBENS; EXPOSURE;
Keywords:
ethanol; serotonin (5-HT); raphe; conditioned taste aversion; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kostowski, W Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, Ul Sobieskiego 1-9, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Ul Sobieskiego 1-9 Warsaw Poland PL-02957
Citazione:
J. Piasecki et al., "Ethanol-induced conditioned taste aversion in the rat: effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus", ALCOHOL, 24(1), 2001, pp. 9-14

Abstract

The effects of lesions of 5-hydroxytryptamine (5-HT) neurons in the dorsalraphe nucleus (DRN) on ethanol-induced conditioned taste aversion were studied in male Wistar rats. Biochemical analysis revealed that a serotonergicneurotoxin, 5.7-dihydroxytryptamine (5,7-DHT), infused into the DRN produced selective depletion of serotonin (i.e., 5-HT) in the frontal cortex and striatum. Conditioned taste aversion to saccharin solution induced by 2 g/kg of ethanol was not affected by the lesion. In contrast, aversion conditioning produced by a lower dose of ethanol (I g/kg) was slightly but significantly attenuated by the 5,7-DHT administration. Taken together with our previous observations, the results of the present study may indicate that central serotonergic projections do not have a primary role in the aversive effects of high doses of ethanol (> 1 g/kg) in the rat. On the other hand, it seems that serotonergic neurons of the DRN may play some modulatory role inthe formation of the avers ive-stimulus properties of moderate doses of ethanol. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:46:11