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Titolo:
Metabolic abnormalities in HIV type 1-infected children treated and not treated with protease inhibitors
Autore:
Melvin, AJ; Lennon, S; Mohan, KM; Purnell, JQ;
Indirizzi:
Univ Washington, Dept Pediat, Div Pediat Infect Dis, Seattle, WA 98105 USAUniv Washington Seattle WA USA 98105 at Infect Dis, Seattle, WA 98105 USA Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 crinol & Nutr, Seattle, WA 98105 USA
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 12, volume: 17, anno: 2001,
pagine: 1117 - 1123
SICI:
0889-2229(20010810)17:12<1117:MAIHT1>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE; BODY-COMPOSITION; YOUNG-ADULTS; RISK-FACTORS; HYPERLIPIDEMIA; LIPODYSTROPHY; ADOLESCENTS; HYPERTRIGLYCERIDEMIA; ATHEROSCLEROSIS; DYSLIPIDEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Melvin, AJ Childrens Hosp & Med Ctr, Div Pediat Infect Dis CH32, 4800 Sandpoint Way NE, Seattle, WA 98105 USA Childrens Hosp & Med Ctr 4800 SandpointWay NE Seattle WA USA 98105
Citazione:
A.J. Melvin et al., "Metabolic abnormalities in HIV type 1-infected children treated and not treated with protease inhibitors", AIDS RES H, 17(12), 2001, pp. 1117-1123

Abstract

Our objective was to determine whether HIV-infected children treated with protease inhibitors (PIs) have different blood lipid, insulin, and glucose levels and body composition than HIV-infected children not treated with Pts. A cross-sectional cohort study was performed; in which 23 children were treated with combination antiretroviral. therapy including a PI for at least6 months and 12 children were treated with nucleoside reverse transcriptase inhibitors only (no-PI group). Levels of lipids, apolipoprotein B (apoB),insulin, and glucose were determined in the fasting state. Body composition and fat distribution were determined by anthropometric measurements and dual energy X-ray absorptiometry (DEXA) scan. Total cholesterol levels were higher in the PI-treated children (5.33 +/- 0.87 mM) than in the no-PI children (3.69 +/- 0.59 mM) (p < 0.0001). Similarly, low-density lipoprotein (LDL) levels were also elevated in the PI-treated children (3.27 +/- 0.76 vs.2.14 +/- 0.51 mM) (p < 0.0001). ApoB and high-density lipoprotein (HDL), and to a lesser degree triglyceride levels, were also increased in the PI-treated children. Apart from percent arm fat as measured by DEXA, there were no differences between the two groups in measures of body composition or intheir fasting glucose and insulin levels. The results from this cross-sectional cohort study suggest that the predominant lipid abnormalities associated with treatment with combination antiretroviral therapy including a PI in HIV-1-infected children are elevated total and LDL cholesterol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:57:22