Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estrogens and cell-cycle regulation in breast cancer
Autore:
Foster, JS; Henley, DC; Ahamed, S; Wimalasena, J;
Indirizzi:
Univ Tennessee, Grad Sch Med, Dept OB GYN, Knoxville, TN 37920 USA Univ Tennessee Knoxville TN USA 37920 ept OB GYN, Knoxville, TN 37920 USA Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya, Sri Lanka Univ Peradeniya Peradeniya Sri Lanka ept Physiol, Peradeniya, Sri Lanka
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 7, volume: 12, anno: 2001,
pagine: 320 - 327
SICI:
1043-2760(200109)12:7<320:EACRIB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA PROTEIN-PHOSPHORYLATION; C-MYC; CDC25A PHOSPHATASE; DEPENDENT KINASES; D1 EXPRESSION; MCF-7 CELLS; INDUCED ACTIVATION; G(1)/S TRANSITION; SIGNALING PATHWAY; E-CDK2 ACTIVATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Wimalasena, J Univ Tennessee, Grad Sch Med, Dept OB GYN, Knoxville, TN 37920 USA Univ Tennessee Knoxville TN USA 37920 oxville, TN 37920 USA
Citazione:
J.S. Foster et al., "Estrogens and cell-cycle regulation in breast cancer", TRENDS ENDO, 12(7), 2001, pp. 320-327

Abstract

Clinical and experimental data have established that the leading cause of sporadic female breast cancer is exposure to estrogens, predominantly 17 beta -estradiol. Recent advances in the understanding of cell-cycle control mechanisms have been applied to outline the molecular mechanisms through which estrogens regulate the cell cycle in cultured breast cancer cells, in particular, in MCF-7 cells. Here, we discuss how estrogens exert control overseveral key G(1) phase cell-cycle regulators, namely cyclin D1, Myc, Cdk2,Cdk4, Cdk inhibitors and Cdc25A. Although the molecular mechanisms underlying estrogenic regulation of G(1) phase regulators are far from clear, current evidence indicates that estrogens might regulate several key molecules required for S phase entry, this regulation being independent of cell-cycletransit per se.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:36:55