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Titolo:
Pathophysiological effects of aldosterone in cardiovascular tissues
Autore:
Rocha, R; Stier, CT;
Indirizzi:
Pharmacia Corp, Cardiovasc & Metab Dis, Skokie, IL 60077 USA Pharmacia Corp Skokie IL USA 60077 vasc & Metab Dis, Skokie, IL 60077 USA New York Med Coll, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 Med Coll, Valhalla, NY 10595 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 7, volume: 12, anno: 2001,
pagine: 308 - 314
SICI:
1043-2760(200109)12:7<308:PEOAIC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; LEFT-VENTRICULAR HYPERTROPHY; INDUCED CARDIAC FIBROSIS; SMOOTH-MUSCLE CELLS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; ANGIOTENSIN-II; HEART-FAILURE; MINERALOCORTICOID RECEPTORS; GLUCOCORTICOID RECEPTOR; MYOCARDIAL-INFARCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Rocha, R Pharmacia Corp, Cardiovasc & Metab Dis, 4901 Searle Pkwy, Skokie,IL 60077USA Pharmacia Corp 4901 Searle Pkwy Skokie IL USA 60077 , IL 60077USA
Citazione:
R. Rocha e C.T. Stier, "Pathophysiological effects of aldosterone in cardiovascular tissues", TRENDS ENDO, 12(7), 2001, pp. 308-314

Abstract

The advent of anti hypertensive therapy has resulted in a significant decrease in cardiovascular morbidity and mortality. Nevertheless, the incidenceof heart failure, stroke and end-stage renal failure continues to increase. This trend suggests that a mechanism, independent of hypertension, is responsible for end-organ damage. Genetic and experimental models of hypertension have demonstrated that excess aldosterone induces severe injury in the heart, brain and kidneys, and that pharmacological antagonism of aldosterone or adrenalectomy markedly reduces myocardial injury, cerebral hemorrhage and renal vascular disease. In clinical studies, plasma aldosterone levels have been shown to correlate with left ventricular hypertrophy, stroke and renal dysfunction. Moreover, aldosterone antagonism has been shown to reduce morbidity and mortality in patients with heart failure. Thus, an increasing body of evidence now indicates that aldosterone is an independent risk factor for cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:23:43