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Titolo:
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders
Autore:
Nishikai, M; Tomomatsu, S; Hankins, RW; Takagi, S; Miyachi, K; Kosaka, S; Akiya, K;
Indirizzi:
Natl Tokyo Med Ctr, Dept Internal Med, Meguro Ku, Tokyo 1528902, Japan Natl Tokyo Med Ctr Tokyo Japan 1528902 , Meguro Ku, Tokyo 1528902, Japan Hlth Sci Res Inst, Yokohama, Kanagawa, Japan Hlth Sci Res Inst Yokohama Kanagawa Japan nst, Yokohama, Kanagawa, Japan Keigu Med Clin, Yokohama, Kanagawa, Japan Keigu Med Clin Yokohama Kanagawa Japan d Clin, Yokohama, Kanagawa, Japan
Titolo Testata:
RHEUMATOLOGY
fascicolo: 7, volume: 40, anno: 2001,
pagine: 806 - 810
SICI:
1462-0324(200107)40:7<806:ATA6KP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP BEHAVIOR DISORDER; ANTINUCLEAR ANTIBODIES; CLASSIFICATION; DEFINITION; INFECTION; ANTIGENS; JAPANESE; CRITERIA; SYSTEM;
Keywords:
anti-6848 kDa protein antibodies; anti-45 kDa protein antibodies; chronic fatigue syndrome; fibromyalgia; antinuclear antibodies; sleep disorders; hypersomnia; insomnia; depression; neurosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nishikai, M Natl Tokyo Med Ctr, Dept Internal Med, Meguro Ku, 2-5-1 Higashigaoka, Tokyo 1528902, Japan Natl Tokyo Med Ctr 2-5-1 Higashigaoka Tokyo Japan 1528902 pan
Citazione:
M. Nishikai et al., "Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders", RHEUMATOLOG, 40(7), 2001, pp. 806-810

Abstract

Objective. To identify antinuclear antibodies (ANA) specific for chronic fatigue syndrome (CFS), and in related conditions such as fibromyalgia (FM) or psychiatric disorders. Methods. One hundred and fourteen CFS patients and 125 primary and secondary FM patients were selected based on criteria advocated by the Centers forDisease Control and Prevention and by the American College of Rheumatology, respectively. As controls, healthy subjects and patients with either various psychiatric disorders or diffuse connective tissue diseases were included. Autoantibodies were examined by immunoblot utilizing HeLa cell extractsas the antigen. Results. Autoantibodies to a 68/48 kDa protein were present in 13.2 and 15.6% of patients with CFS and primary FM, respectively. In addition, autoantibodies to a 45 kDa protein were found in 37.1 and 21.6% of the patients with secondary FM and psychiatric disorders, respectively. Meanwhile, these two autoantibodies were not found at all in connective tissue disease patients without FM, nor in healthy subjects (P < 0.05). As a group, the anti-68/48 kDa-positive CFS patients presented more frequently with hypersomnia (P < 0.005), short-term amnesia (P < 0.07) or difficulty in concentration (P <0.05) than those CFS patients without the antibodies. Conclusions. The presence of the anti-68/48 kDa protein antibodies in a portion or both CFS and primary FM patients suggests the existence of a common immunological background. These antibodies may find utility as possible markers for a clinicoserological subset of CFS, FM patients with hypersomniaand cognitive complaints.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:35:42