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Titolo:
Effect of dioxin on ovarian function in the cynomolgus macaque (M-fascicularis)
Autore:
Moran, FM; Tarara, R; Chen, J; Santos, S; Cheney, A; Overstreet, JW; Lasley, BL;
Indirizzi:
Univ Calif Davis, Inst Toxicol & Environm Hlth, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 & Environm Hlth, Davis, CA 95616 USA Univ Calif Davis, Calif Reg Primate Res Ctr, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Primate Res Ctr, Davis, CA 95616 USA Univ Calif Davis, Dept Populat Hlth & Reprod, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 at Hlth & Reprod, Davis, CA 95616 USA
Titolo Testata:
REPRODUCTIVE TOXICOLOGY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 377 - 383
SICI:
0890-6238(200107/08)15:4<377:EODOOF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; LUTEINIZED GRANULOSA-CELLS; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN TCDD; MACACA-MULATTA; REPRODUCTIVE TOXICITY; RHESUS MACAQUE; IN-UTERO; EXPOSURE; ESTRADIOL; RATS;
Keywords:
endocrine disruption; primate; reproduction; steroidogenesis; TCDD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lasley, BL Univ Calif Davis, Inst Toxicol & Environm Hlth, Davis, CA 95616USA Univ Calif Davis Davis CA USA 95616 Hlth, Davis, CA 95616 USA
Citazione:
F.M. Moran et al., "Effect of dioxin on ovarian function in the cynomolgus macaque (M-fascicularis)", REPROD TOX, 15(4), 2001, pp. 377-383

Abstract

Ovarian function was evaluated in mature female cynomolgus macaques 443 to625 days following a single oral exposure (1, 2, or 4 mug/kg BW) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Urinary estrone conjugates (EIC), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were measured. Three of four animals in the high dose group had no evidence of menstrual cycles while animals in the low and medium dose groups plus one from the high dose group had cycles that were similar to those of control animals. The noncycling animals had baseline E1C concentrations without ovulatory midcycle peaks and monotonic PdG profiles. Mean FSH concentrations during the midfollicular phase of the medium dose group and during the entire cycle of the high dose group were elevated compared to those of the control group and the endometria of the noncycling animals were inactive. These data demonstrate that a single exposure of 4 mug/kg BW TCDD leads to long-termadverse effects on ovarian function in primates. (C) 2001 Elsevier ScienceInc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:05:12