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Titolo:
Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys
Autore:
Paronis, CA; Cox, ED; Cook, JM; Bergman, J;
Indirizzi:
Harvard Univ, Sch Med, McLean Hosp, Belmont, MA 02478 USA Harvard Univ Belmont MA USA 02478 Med, McLean Hosp, Belmont, MA 02478 USA Univ Wisconsin, Dept Chem, Milwaukee, WI 53201 USA Univ Wisconsin Milwaukee WI USA 53201 Dept Chem, Milwaukee, WI 53201 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 156, anno: 2001,
pagine: 461 - 468
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTORS; ALCOHOL ANTAGONIST; PARTIAL AGONISTS; TRAINED SUBJECTS; PHARMACOLOGY; SUBTYPES; SUBUNIT; LIGANDS; CL-284,846; INCREASES;
Keywords:
benzodiazepine; schedule-controlled responding; monkey; midazolam; flumazenil; beta-CCt; zolpidem; zaleplon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Paronis, CA Harvard Univ, Sch Med, McLean Hosp, 115 Mill St, Belmont, MA 02478 USA Harvard Univ 115 Mill St Belmont MA USA 02478 nt, MA 02478 USA
Citazione:
C.A. Paronis et al., "Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys", PSYCHOPHAR, 156(4), 2001, pp. 461-468

Abstract

Rationale: The role of different types of GABAA receptors in mediating anticonflict and response rate-decreasing effects of benzodiazepines in primate species is not known. Objective: To examine the behavioral effects of thebenzodiazepine-site, GABAA agonists zolpidem, zaleplon, and midazolam in the presence of two antagonists, flumazenil and beta -carboline-3-carboxylate-t-butyl ester (beta -CCt) in squirrel monkeys. Methods: Two schedules of operant responding were used: (1) a multiple fixed-ratio (FR) schedule of food presentation involving punished and nonpunished behavior, and (2) an FRschedule of stimulus shock-termination. Results: Midazolam (0.03-1.0 mg/kg), zolpidem (0.1-3.0 mg/kg), and zaleplon (0.1-3.0 mg/kg) increased rates of punished responding and decreased rates of nonpunished responding under the multiple schedule. Pretreatment with flumazenil (0.3-1.0 mg/kg) antagonized the anticonflict and response rate-decreasing effects of all three agonists. Pretreatment with beta -CCt (3-10 mg/kg) antagonized the anticonflictand rate-decreasing effects of midazolam, as well as the rate-decreasing effects of zolpidem and zaleplon. However, beta -CCt did not antagonize the anticonflict effects of zolpidem and zaleplon; instead, these effects of zolpidem and zaleplon were apparently enhanced in the presence of beta -CCt. Under the schedule of stimulus shock-termination, both flumazenil and beta -CCt antagonized zolpidem and zaleplon; however, the effects of beta -CCt were less consistent than the effects of flumazenil. Conclusion: In nonhumanprimates, different types of GABAA receptors may mediate the anticonflict and the response rate-decreasing effects of the nonselective GABAA agonist midazolam and the selective GABA(A1) agonists zolpidem and zaleplon.

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Documento generato il 04/12/20 alle ore 13:21:29