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Titolo:
Opposite effects of nefazodone in two human models of anxiety
Autore:
Silva, M; Hetem, LAB; Guimaraes, FS; Graeff, FG;
Indirizzi:
Univ Sao Paulo, FFMRP, Dept Neurol Psychiat & Med Psychol, BR-14025000 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14025000 BCibeirao Preto, Brazil Univ Sao Paulo, FFMRP, Dept Pharmacol, BR-14025000 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14025000 BCibeirao Preto, Brazil
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 156, anno: 2001,
pagine: 454 - 460
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMULATED PUBLIC-SPEAKING; D-FENFLURAMINE; PANIC DISORDER; SEROTONIN ANTAGONIST; HEALTHY-VOLUNTEERS; RITANSERIN; FLUVOXAMINE; PLACEBO; 5-HT; 5-HYDROXYTRYPTAMINE;
Keywords:
serotonin; nefazodone; experimental anxiety; healthy volunteers; conditioning of skin conductance responses simulated public speaking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Graeff, FG Univ Sao Paulo, FFMRP, Dept Neurol Psychiat & Med Psychol, Av Nove de Julho 980, BR-14025000 Ribeirao Preto, Brazil Univ Sao Paulo Av Novede Julho 980 Ribeirao Preto Brazil BR-14025000 BC
Citazione:
M. Silva et al., "Opposite effects of nefazodone in two human models of anxiety", PSYCHOPHAR, 156(4), 2001, pp. 454-460

Abstract

Rationale and objectives: To explore further the role of serotonin (5-HT) in anxiety, the effects of the 5-HT reuptake inhibitor and 5-HT-(2A) receptor antagonist nefazodone (NF) were measured in two human models of anxiety. Methods: Twenty-nine adult healthy volunteers of both sexes underwent conditioning of skin conductance responses (CSCR) to a tone associated to an aversive white noise. Another 34 subjects performed a simulated public speaking (SPS) task, seemingly related to unconditioned fear. In both tests, subjective states were evaluated through the visual analogue mood scale (VAMS) and a bodily symptoms scale (BSS). In each experiment subjects were randomly divided into three groups, which received 100 mg NF, 200 mg NF or placebounder double-blind condition. Results: In the CSCR test, NF decreased the number of spontaneous fluctuations of skin conductance (F=4.94; dP=2,26; P=0.015). In addition, the increase in VAMS anxiety factor induced by the conditioning task was attenuated by NF (F=11.11; df=2,26; P <0.001). In contrast, the rise of VAMS anxiety induced by SPS was enhanced by NF (F=8.01; df=2,31; P=0.002). Conclusions: These results indicate that NF decreases conditioned anxiety, while enhancing unconditioned fear. Since the effects of NFmay be due to impairment of 5-HT neurotransmission, consequent to overstimulation of autosomic 5-HT1A receptors and blockade of post-synaptic 5-HT2A receptors, the present results support the hypothesis that 5-HT facilitatesconditioned anxiety, which may be related to generalised anxiety disorder,while inhibiting unconditioned fear, supposedly related to panic disorder.

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Documento generato il 09/04/20 alle ore 00:21:08