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Titolo:
A randomized study comparing oral and standard regimens for metastatic breast cancer
Autore:
Hori, T; Kodama, H; Nishimura, S; Hatano, T; Okamura, R; Fujii, K; Kudo, T; Inamoto, T; Sawai, K; Kobayashi, M; Ogawa, H; Yoshimura, N; Hiraoka, M;
Indirizzi:
Kyoto Police Hosp, Dept Surg, Keiji Breast Canc Study Grp, Kita Ku, Kyoto 6038142, Japan Kyoto Police Hosp Kyoto Japan 6038142 Grp, Kita Ku, Kyoto 6038142, Japan Kodama Breast Clin, Kodama, Japan Kodama Breast Clin Kodama JapanKodama Breast Clin, Kodama, Japan Kansai Med Univ, Otokoyama Hosp, Kansai, Japan Kansai Med Univ Kansai Japan ai Med Univ, Otokoyama Hosp, Kansai, Japan Kyoto City Hosp, Kyoto, Japan Kyoto City Hosp Kyoto JapanKyoto City Hosp, Kyoto, Japan Kyoto Second Red Cross Hosp, Kyoto, Japan Kyoto Second Red Cross Hosp Kyoto Japan nd Red Cross Hosp, Kyoto, Japan Kyoto Natl Hosp, Kyoto, Japan Kyoto Natl Hosp Kyoto JapanKyoto Natl Hosp, Kyoto, Japan Kyoto Univ, Sch Med, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Sch Med, Kyoto, Japan Kyoto Prefectural Univ Med, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 al Univ Med, Kyoto 602, Japan Nantan City Hosp, Nantan, Japan Nantan City Hosp Nantan JapanNantan City Hosp, Nantan, Japan Ohtsu Red Cross Hosp, Otsu, Shiga, Japan Ohtsu Red Cross Hosp Otsu Shiga Japan Red Cross Hosp, Otsu, Shiga, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 5, volume: 8, anno: 2001,
pagine: 1067 - 1071
SICI:
1021-335X(200109/10)8:5<1067:ARSCOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDROXYPROGESTERONE ACETATE; 5'-DEOXY-5-FLUOROURIDINE;
Keywords:
metastatic breast cancer; doxifluridine; standard therapy; oral therapy; phase III study; capecitabine; medroxyprogesterone acetate; cyclophosphamide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, T Kyoto Police Hosp, Dept Surg, Keiji Breast Canc Study Grp, Kita Ku, 14 Koyama Kitakamifusacho, Kyoto 6038142, Japan Kyoto Police Hosp 14 Koyama Kitakamifusacho Kyoto Japan 6038142 n
Citazione:
T. Hori et al., "A randomized study comparing oral and standard regimens for metastatic breast cancer", ONCOL REP, 8(5), 2001, pp. 1067-1071

Abstract

We conducted a randomized controlled trial comparing oral regimen [doxifluridine, an intermediate metabolite of capecitabine, + medroxyprogesterone acetate (MPA) + cyclophosphamide (CPA)] (Method A) with a standard regimen (5-fluorouracil + adriamycin + CPA) plus MPA (Method B) as first line chemotherapy for metastatic breast cancer. Overall response rate was 55.8% for Method A, 46.3% for Method B. The total ratio of responder and long stable disease was significantly higher with Method A (p=0.006). Median time to progression and survival were not differences between Methods. Incidence of toxicity was 56.3% with Method A and 80.0% with Method B (p=0.014). Oral regimen is more useful than standard therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:49:36