Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of DNA mismatch repair proteins hMSH2 and hMLH1 and the cyclin G1 inhibitor, p21(waf1/cip1) in pediatric tumors: Correlation with responseto therapy
Autore:
Idikio, HA;
Indirizzi:
Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 hol, Edmonton, AB T6G 2B7, Canada
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 5, volume: 8, anno: 2001,
pagine: 965 - 971
SICI:
1021-335X(200109/10)8:5<965:EODMRP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPORADIC GASTRIC CARCINOMAS; CELL NUCLEAR ANTIGEN; HUMAN SARCOMA-CELLS; DRUG-RESISTANCE; MICROSATELLITE INSTABILITY; OVARIAN-CANCER; ACQUIRED-RESISTANCE; ESOPHAGEAL CANCER; BREAST-CARCINOMA; DEFICIENT CELLS;
Keywords:
DNA mismatch repair; hMSH2; hMLH1; p21 (waf1/cip1) childhood cancers; treatment response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Idikio, HA Univ Alberta, Univ Alberta Hosp 8440, Dept Lab Med & Pathol, 112th St, Edmonton, AB T6G 2B7, Canada Univ Alberta 112th St Edmonton AB Canada T6G 2B7 6G 2B7, Canada
Citazione:
H.A. Idikio, "Expression of DNA mismatch repair proteins hMSH2 and hMLH1 and the cyclin G1 inhibitor, p21(waf1/cip1) in pediatric tumors: Correlation with responseto therapy", ONCOL REP, 8(5), 2001, pp. 965-971

Abstract

The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anticancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) inpediatric tumor responses to chemotherapy and irradiation is described in the present study of 23 pediatric solid cancers (4 Wilms' tumors, 9 neuroblastomas, 3 hepatoblastomas, 3 lymphomas and 4 sarcomas) using immunohistochemical methods. Immunostaining was scored for intensity (0-3) and extent (0-3). Most tumors stained strongly for hMSH2 and weakly or negative for hMLH1. All the hMLH1 negative tumors (1 Wilms', 1 hepatoblastoma, 1 sarcoma, 2 lymphomas and 2 neuroblastomas) achieved complete response. p21(waf1) negative and positive tumors achieved relatively similar treatment response. Theresults suggest that the expression of DNA mismatch repair proteins hMLH1 and hMSH2, and p21(waf1) do not influence individual cancer responses to treatment and the results may reflect the use of multiple drugs and irradiation that cause many different types of DNA damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:06:26