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Titolo:
Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8
Autore:
Inoue, K; Wood, CG; Slaton, JW; Karashima, T; Sweeney, P; Dinney, CPN;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Canc Biol, Houston, TX 77030 USA
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 5, volume: 8, anno: 2001,
pagine: 955 - 964
SICI:
1021-335X(200109/10)8:5<955:AGTOHB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; RNA HYBRIDIZATION TECHNIQUE; COLON-CARCINOMA CELLS; HUMAN-MELANOMA CELLS; MESSENGER-RNA; NUDE-MICE; PROSTATE CARCINOMA; FACTOR RECEPTOR; ANGIOGENESIS; EXPRESSION;
Keywords:
IL-8; gene therapy; angiogenesis; bladder cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dinney, CPN Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 X 77030 USA
Citazione:
K. Inoue et al., "Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8", ONCOL REP, 8(5), 2001, pp. 955-964

Abstract

We previously demonstrated the importance of interleukin-8 (IL-8) as a mediator of angiogenesis, tumorigenicity, and metastasis of transitional cell carcinoma (TCC) of the bladder. In the present study, we evaluated the feasibility of adenoviral mediated antisense IL-8 gene transfer (Ad IL-8-AS) astherapy for established TCC. In vitro, Ad IL-8-AS inhibited endothelial cell proliferation and enhanced endothelial cell apoptosis. The highly metastatic human TCC cell line 253J B-V-R was implanted into the subcutis of athymic nude mice, and intralesional therapy with Ad IL-8-AS commenced when thetumors reached a diameter between 5 and 7 mm. Tumor growth was significantly inhibited compared with therapy in controls (saline and beta -galactosidase adenovirus). Ad IL-8-AS therapy decreased the in vivo expression of IL-8 and matrix metalloproteinase type 9 (MMP-9), reduced microvessel density,and enhanced endothelial cell apoptosis. These results indicate that Ad IL-8-AS therapy targets both tumor cells and host endothelial cells resultingin endothelial cell apoptosis and significant inhibition of tumor growth.

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Documento generato il 06/04/20 alle ore 08:33:30