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Titolo:
Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney
Autore:
Ishiguro, H; Tsunoda, T; Tanaka, T; Fujii, Y; Nakamura, Y; Furukawa, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 l Med Lab,Minato Ku, Tokyo 1088639, Japan RIKEN, Inst Phys & Chem Res, SNP Res Ctr, Minato Ku, Tokyo 1088639, Japan RIKEN Tokyo Japan 1088639 , SNP Res Ctr, Minato Ku, Tokyo 1088639, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan
Titolo Testata:
ONCOGENE
fascicolo: 36, volume: 20, anno: 2001,
pagine: 5062 - 5066
SICI:
0950-9232(20010816)20:36<5062:IOAANH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOMATOUS POLYPOSIS-COLI; BETA-CATENIN MUTATIONS; WNT SIGNALING PATHWAY; NEGATIVE REGULATOR; HEPATOCELLULAR CARCINOMAS; COLORECTAL CARCINOMAS; CYCLIN D1; CANCER; ACTIVATION; APC;
Keywords:
AXIN1; chromosome 3p22; colon cancer; lung cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, Y Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,MinatoKu, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 ShirokanedaiTokyo Japan 1088639 8639, Japan
Citazione:
H. Ishiguro et al., "Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney", ONCOGENE, 20(36), 2001, pp. 5062-5066

Abstract

Axin, an important regulator of beta -catenin, is frequently mutated in human hepatocellular carcinomas (HCCs), and transduction of the wild-type Axin gene (AXIN1) induces apoptosis in HCC cells as well as in colon cancer cells. To investigate the detailed biological function of Axin, we searched on a cDNA microarray for genes whose expression was altered by transfer of wild-type AXIN1 into colon-cancer cell line LoVo. Among the genes showing altered expression, we focused on one, termed AXUD1 (AXIN1 up-regulated(1)), that revealed enhanced expression in response to exogeneously expressed AXIN1 but not to LacZ, a control gene. The AXUD1 gene consists of five exons and encodes a transcript with an open reading frame of 1767 bp. A 3.2-kb transcript of AXUD1 was expressed in all human tissues examined, most abundantly in lung, placenta, skeletal muscle, pancreas and leukocyte. By radiation-hybrid mapping we assigned its chromosomal location at 3p22, a region where frequent loss of heterozygosity has been reported in lung, renal, prostate, breast and cervical cancers. AXUD1 was frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues, suggesting that AXUD1 may have a tumor-suppressor function in those organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:40:25