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Titolo:
Genetic loci controlling susceptibility to gamma-ray-induced thymic lymphoma
Autore:
Saito, Y; Ochiai, Y; Kodama, Y; Tamura, Y; Togashi, T; Kosugi-Okano, H; Miyazawa, T; Wakabayashi, Y; Hatakeyama, K; Wakana, S; Niwa, O; Kominami, R;
Indirizzi:
Niigata Univ, Sch Med, Dept Biochem 1, Niigata 9518122, Japan Niigata Univ Niigata Japan 9518122 ept Biochem 1, Niigata 9518122, Japan Niigata Univ, Sch Med, Dept Surg 1, Niigata 9518122, Japan Niigata Univ Niigata Japan 9518122 , Dept Surg 1, Niigata 9518122, Japan Kyoto Univ, Inst Phys, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Inst Phys, Kyoto, Japan Kyoto Univ, Chem Res Genome Sci Ctr, Kyoto, Japan Kyoto Univ Kyoto Japan yoto Univ, Chem Res Genome Sci Ctr, Kyoto, Japan Kyoto Univ, Ctr Radiat Biol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606Kyoto Univ, Ctr Radiat Biol, Kyoto 606, Japan
Titolo Testata:
ONCOGENE
fascicolo: 37, volume: 20, anno: 2001,
pagine: 5243 - 5247
SICI:
0950-9232(20010823)20:37<5243:GLCSTG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL NEOPLASIA; CANCER SUSCEPTIBILITY; SUPPRESSOR GENE; DEFICIENT MICE; COMPLEX TRAITS; MAJOR MODIFIER; COLON-CANCER; MOUSE; RESISTANCE; TUMORS;
Keywords:
susceptibility gene; genetic mapping; gamma-ray radiation; mouse thymic lymphoma; congenic mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kominami, R Niigata Univ, Sch Med, Dept Biochem 1, Asahimachi 1-757, Niigata 9518122, Japan Niigata Univ Asahimachi 1-757 Niigata Japan 9518122 22, Japan
Citazione:
Y. Saito et al., "Genetic loci controlling susceptibility to gamma-ray-induced thymic lymphoma", ONCOGENE, 20(37), 2001, pp. 5243-5247

Abstract

BALB/c is a susceptible strain for the development of gamma -ray induced mouse thymic lymphoma whereas MSM shows resistance. Association analysis of 220 backcross mice between the two strains using 67 markers was carried outto identify loci involved in the control of susceptibility. The genotype of mice with lymphoma showed excess heterozygosity relative to MSM homozygosity at D2Mit15 and D4Mit12 and was skewed toward MSM-derived alleles at D5Mit5. The P values in Mantel-Cox test were 0.0048 (D2Mit15), 0.0034 (D4Mit12) and 0.0048 (D5Mit5), suggesting association at the three loci in the susceptibility. Cooperative effect on lymphomagenesis was also observed among the three loci. To obtain independent evidence for linkage at D4Mit12, we made partially congenic mice in which a D4Mit12 region in BALB/c was replacedby MSM-derived homolog. Examination for the lymphoma susceptibility in 78 progeny of the congenic mice confirmed the effect of the locus near D4Mit12(P=0.0037). The result, together with the linkage analysis, shows that thelocus near D4Mit12 is regarded as a confirmed linkage but the other two loci as marginally suggestive.

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Documento generato il 09/04/20 alle ore 05:08:53