Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Functional cooperation between JunD and NF-kappa B in rat hepatocytes
Autore:
Rahmani, M; Peron, P; Weitzman, J; Bakiri, L; Lardeux, B; Bernuau, D;
Indirizzi:
Univ Paris 07, INSERM, U327, Biol Cellulaire Lab, F-75018 Paris, France Univ Paris 07 Paris France F-75018 Cellulaire Lab, F-75018 Paris, France Univ Paris 07, F-75018 Paris, France Univ Paris 07 Paris France F-75018Univ Paris 07, F-75018 Paris, France Inst Pasteur, Dept Biotechnol, CNRS, Unite Virus Oncogenes,URA 1644, Paris, France Inst Pasteur Paris France Unite Virus Oncogenes,URA 1644, Paris, France
Titolo Testata:
ONCOGENE
fascicolo: 37, volume: 20, anno: 2001,
pagine: 5132 - 5142
SICI:
0950-9232(20010823)20:37<5132:FCBJAN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GM-CSF PROMOTER; C-JUN; GLUCOCORTICOID RECEPTOR; LIVER-REGENERATION; TRANSCRIPTION FACTORS; AP-1 COMPLEX; DNA-BINDING; ACTIVATES TRANSCRIPTION; HEPATIC REGENERATION;
Keywords:
NF-kappa B; p65; AP-1; JunD; hepatocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Bernuau, D Univ Paris 07, INSERM, U327, Biol Cellulaire Lab, 16 Rue Henri Huchard, F-75018 Paris, France Univ Paris 07 16 Rue Henri Huchard Paris France F-75018 France
Citazione:
M. Rahmani et al., "Functional cooperation between JunD and NF-kappa B in rat hepatocytes", ONCOGENE, 20(37), 2001, pp. 5132-5142

Abstract

AP-I and NF-kappaB are rapidly activated during liver regeneration. Whether these parallel inductions have potential functional implications is not known. Isolated rat hepatocytes were stimulated with two mitogens, epidermalgrowth factor or hepatocyte growth factor and with tumor necrosis factor, a cytokine involved in the liver regenerative response in vivo and a stronginducer of NF-kappaB. All three cytokines increased AP-1 and NF-kappaB binding to their cognate cis-element and induced a 2.5-fold activation of NF-kappaB-dependent transcription. Inactivation of AP-I by TAM67, a dominant negative mutant of AP-I drastically inhibited basal and cytokine-induced NF-kappaB transactivation. Overexpression of Jun D, but not of the other Jun orFos proteins increased by threefold NF-kappaB transactivation. Functional cooperation between JunD and p65 was demonstrated in a simple Gal-hybrid system. Finally, a twofold decrease in NF-kappaB transactivation was found inhepatocytes isolated from JunD (-/-) mice compared with hepatocytes from JunD(+/+) mice. Altogether these data demonstrate a functional cooperation of p65 with JunD, a major constituent of AP-1 in normal hepatocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:22:36