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Titolo:
Successful surgical relief of seizures associated with hamartoma of the floor of the fourth ventricle in children: Report of two cases
Autore:
Delalande, O; Rodriguez, D; Chiron, C; Fohlen, M;
Indirizzi:
Hop St Vincent de Paul, Neuropediat Dept, F-75674 Paris, France Hop St Vincent de Paul Paris France F-75674 Dept, F-75674 Paris, France Fdn Ophtalmol A de Rothschild, Pediat & Epilepsy Neurosurg Dept, Paris, France Fdn Ophtalmol A de Rothschild Paris France eurosurg Dept, Paris, France
Titolo Testata:
NEUROSURGERY
fascicolo: 3, volume: 49, anno: 2001,
pagine: 726 - 730
SICI:
0148-396X(200109)49:3<726:SSROSA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMIFACIAL SPASM; HYPOTHALAMIC HAMARTOMAS; INTRINSIC EPILEPTOGENICITY; GELASTIC SEIZURES; EPILEPSY; GANGLIOGLIOMA; INFANCY; EEG;
Keywords:
brainstem; children; epilepsy; floor of the fourth ventricle; hamartoma; neurosurgery; seizure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fohlen, M Fdn Adolphe De Rothschild, Serv Neurochirurg, 25 Rue Manin, F-75019 Paris,France Fdn Adolphe De Rothschild 25 Rue Manin Paris France F-75019 nce
Citazione:
O. Delalande et al., "Successful surgical relief of seizures associated with hamartoma of the floor of the fourth ventricle in children: Report of two cases", NEUROSURGER, 49(3), 2001, pp. 726-730

Abstract

Objective and importance: To discuss the physiopathology and Surgical handling of seizures due to hamartoma of the floor of the fourth ventricle in two children. Clinical presentation: Two girls aged 3 years at the time of their operations presented with seizures due to a lesion of the floor of the fourth ventricle. The seizures began within the first days of life and consisted of hemifacial contraction, then head deviation, blinking of the eyelids, and intermittent dysautonomic manifestations. The interictal neurological condition seemed normal in one patient and showed a slight development delay in theother. An ictal electroencephalogram showed slow waves in the posterior areas. A magnetic resonance imaging scan revealed a mass that remained unchanged on serial examinations bordering the fourth ventricle, with an isointense signal on Ti-weighted sequences and high-intensity signals on T2-weighted sequences without gadolinium enhancement. An ictal single-photon emissioncomputed tomographic scan showed hyperperfusion in the lesion in both girls. Intervention: The operation consisted of resection and disconnection of the lesion. An electrical recording was obtained in one patient during the operation while she was anesthetized; the recording, made by means of a depthelectrode with five contacts inside the lesion, indicated that repetitive theta rhythmic discharges were present. Neuropathology was consistent with a hamartoma. In both girls, the seizures disappeared after their operations, and antiepileptic drugs were withdrawn (follow-up periods, 8 and 3 yr, respectively). Conclusion: Considering the results of single-photon emission computed tomography, the intralesional electrical record, and the relief of seizures after the operation, we postulate that the seizures arose from inside the lesion. This particular kind of noncortical seizure is similar to gelastic seizure due to hypothalamic hamartoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:25:07