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Titolo:
Effects of synthetic dopamine-melanins on oxygen radical - Formation induced by metal ions with dopamine
Autore:
Kimura, S; Kurasaki, M; Saito, T; Ito, K; Hosokawa, T; Okabe, M; Shiraishi, K; Niioka, T;
Indirizzi:
Hokkaido Univ, Grad Sch Environm Earth Sci, Dept Environm Med & Informat, Sapporo, Hokkaido 0600810, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600810 oro, Hokkaido 0600810, Japan Natl Inst Radiol Sci, Div Human Radiat Environm, Chiba 260, Japan Natl Inst Radiol Sci Chiba Japan 260 n Radiat Environm, Chiba 260, Japan Hokkaido Univ, Sch Med, Lab Environm Biol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Sci Tanaka Co Ltd, Inst Biotechnol, Ishikari, Hokkaido, Japan Sci Tanaka Co Ltd Ishikari Hokkaido Japan nol, Ishikari, Hokkaido, Japan Hokkaido Univ, Ctr Res & Dev Higher Educ, Res Div Higher Educ, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan gher Educ, Sapporo, Hokkaido, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 29, anno: 2001,
pagine: 31 - 40
SICI:
0893-6609(200107/08)29:1<31:EOSDOO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SUBSTANTIA-NIGRA; PARKINSONIAN BRAINS; NEUROMELANIN; IRON; IRON(III); DAMAGE; RAT;
Keywords:
DNA cleavage; synthetic dopamine-melanins; neuromelanin; metals; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, S Hokkaido Univ, Grad Sch Environm Earth Sci, Dept Environm Med & Informat, Sapporo, Hokkaido 0600810, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600810 ido 0600810, Japan
Citazione:
S. Kimura et al., "Effects of synthetic dopamine-melanins on oxygen radical - Formation induced by metal ions with dopamine", NEUROSC R C, 29(1), 2001, pp. 31-40

Abstract

To understand the possible physiological roles of the neuromelanins, we examined effects of synthetic dopamine-melanins on oxygen radical formation by metal ions with dopamine. Oxygen radical formation was detected by DNA cleavage analysis. Addition of metal-free synthetic dopamine-melanins inhibited DNA cleavage induced by Fe or Cu ions with dopamine. On the other hand, in the presence of dopamine, dopamine-melanins loaded with Cu and Fe induced DNA cleavage without addition of free metal ions. It was clarified that dopamine-melanins loaded with Cu and Fe generated hydroxyl radicals in the presence of dopamine, on the basis of the findings that catalase and mannitol inhibited the DNA cleavage. Our results suggest that metal-free neuromelanins inhibit hydroxyl radical formation induced by metal ions with dopamineby sequestering metal ions.

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Documento generato il 22/01/20 alle ore 06:27:07