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Titolo:
Protection of nigral neurons by GDNF-engineered marrow cell transplantation
Autore:
Park, KW; Eglitis, MA; Mouradian, MM;
Indirizzi:
NINDS, Genet Pharmacol Unit, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Therapeut Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 40, anno: 2001,
pagine: 315 - 323
SICI:
0168-0102(200108)40:4<315:PONNBG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROTROPHIC FACTOR PROTECTS; BLOOD-BRAIN-BARRIER; BONE-MARROW; STROMAL CELLS; DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; IN-VIVO; C57BL/6 MICE; GENE-THERAPY; ADULT MICE;
Keywords:
Parkinson; MPTP; GDNF; transplantation; gene therapy; bone marrow; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Park, KW Korea Univ, Dept Neurol, Coll Med, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 , Seoul 136701, South Korea
Citazione:
K.W. Park et al., "Protection of nigral neurons by GDNF-engineered marrow cell transplantation", NEUROSCI RE, 40(4), 2001, pp. 315-323

Abstract

Marrow stromal cells, which have many characteristics of stem cells, populate various non-hematopoietic tissues including the brain. In the present study, the cDNA for the dopaminergic neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor (GDNF) was delivered using marrow cells in the mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) model of Parkinson's disease. Following cross-sex intravenous bone marrow transplantation withmate donor cells that had been transduced with GDNF (GDNF-BMT) or with non-manipulated marrow (Control-BMT), female recipient mice were subjected to systemic MPTP injections. Eight weeks after neurotoxin exposure, more tyrosine hydroxylase immunoreactive nigral neurons and striatal terminal densitywere observed in the GDNF-BMT mice compared with the Control-BMT group. Inaddition. following the expected initial behavioral hyperactivity in both groups, a significant difference in motor activity was detected between thetwo groups. GDNF immunoreactive mate donor marrow derived cells were detected in the brains of GDNF-BMT mice but not in controls. These data indicatethat marrow derived cells that seed the brain can express biologically active gene products and, therefore, can function as effective vehicles for therapeutic gene transfer to the brain. (C) 2001 Elsevier Science Ireland Ltdand the Japan Neuroscience Society. All rights reserved.

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Documento generato il 28/03/20 alle ore 23:05:28