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Titolo:
Visualizing synapse formation and remodeling: recent advances in real-timeimaging of CNS synapses
Autore:
Umeda, T; Okabe, S;
Indirizzi:
Tokyo Med & Dent Univ, Dept Anat & Cell Biol, Sch Med, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Natl Inst Biosci & Human Technol, Mol Neurobiol Lab, Tsukuba, Ibaraki 3058566, Japan Natl Inst Biosci & Human Technol Tsukuba Ibaraki Japan 3058566 566, Japan Japan Sci & Technol Corp, JST, CREST, Tokyo, Japan Japan Sci & Technol Corp Tokyo Japan nol Corp, JST, CREST, Tokyo, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 40, anno: 2001,
pagine: 291 - 300
SICI:
0168-0102(200108)40:4<291:VSFARR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; POSTSYNAPTIC DENSITY PROTEIN; CULTURED HIPPOCAMPAL-NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; EVOKED DENDRITIC EXOCYTOSIS; GREEN FLUORESCENT PROTEINS; PRESYNAPTIC ACTIVE ZONES; NMDA RECEPTOR; RAT-BRAIN; KINASE-II;
Keywords:
green fluorescent protein (GFP); FM-dye; synapse; synaptogenesis; central nervous system (CNS); postsynaptic density (PSD); exocytosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Umeda, T Tokyo Med & Dent Univ, Dept Anat & Cell Biol, Sch Med, Bunkyo Ku,1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 , Japan
Citazione:
T. Umeda e S. Okabe, "Visualizing synapse formation and remodeling: recent advances in real-timeimaging of CNS synapses", NEUROSCI RE, 40(4), 2001, pp. 291-300

Abstract

The formation and maintenance of synaptic connections are critical in the development and plasticity of the central nervous system (CNS). Until recently, there have been few studies that followed the molecular sequences of the CNS synapse formation and maintenance. This situation changed dramatically after the introduction of green fluorescent protein (GFP)-based fluorescent probes and the development of lipophilic tracers of endocytotic membranes. These techniques enabled us to visualize presynaptic and postsynaptic structures in living neurons and illustrated active transport and remodelingof synaptic components. Furthermore, recent attempts to identify correlation between presynaptic and postsynaptic morphogenesis suggested very rapid time course of synapse formation at the individual axo-dendritic contact sites. These recent works clearly demonstrated the power of real-time imagingstudies. Development of a wide variety of fluorescent probes and advances in the imaging techniques in future will further extend our knowledge on the molecular events that take place in the process of the development and maturation of synaptic junctions. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:35:44