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Titolo:
Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol
Autore:
Lukoyanov, NV; Paula-Barbosa, MM;
Indirizzi:
Porto Med Sch, Dept Anat, P-4200319 Oporto, Portugal Porto Med Sch Oporto Portugal P-4200319 Anat, P-4200319 Oporto, Portugal
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 309, anno: 2001,
pagine: 45 - 48
SICI:
0304-3940(20010817)309:1<45:MBNDAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; ETHANOL WITHDRAWAL; RADIAL-ARM; SEIZURES; MK-801; NEUROTOXICITY; PERFORMANCE; IMPAIRMENT; COMPLEX;
Keywords:
ethanol withdrawal; N-methyl-D-aspartate antagonists; water maze; learning and memory; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lukoyanov, NV Porto Med Sch, Dept Anat, Alameda Professor Hernani Monteiro, P-4200319 Oporto, Portugal Porto Med Sch Alameda Professor Hernani Monteiro Oporto Portugal P-4200319
Citazione:
N.V. Lukoyanov e M.M. Paula-Barbosa, "Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol", NEUROSCI L, 309(1), 2001, pp. 45-48

Abstract

Adult rats were given a 20% ethanol solution as their only source of fluidfor 6 months and then withdrawn from alcohol. During the first 4 weeks of the withdrawal period, animals were intraperitoneally injected with either memantine (20 mg/kg bolus followed by 1 mg/kg every 12 h) or dizocilpine (MK-801; 0.1 mg/kg every 12 h), both of which are antagonists of N-methyl-D-aspartate receptors. Ten weeks after initiation of the withdrawal procedure,cognitive status of animals was assessed using the Morris water maze. Withdrawal from alcohol produced robust deficits in the performance of rats on the acquisition task and on the probe trial. Treatment with memantine resulted in a complete reversal of these behavioral impairments. In contrast, treatment with MK-801 was found to be ineffective in preventing cognitive alterations associated with chronic alcohol consumption and withdrawal. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:23:51