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Titolo:
Association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients
Autore:
Liao, DL; Yeh, YC; Chen, HM; Chen, H; Hong, CJ; Tsai, SJ;
Indirizzi:
Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan Vet Gen Hosp Taipei Taiwan 11217 sp, Dept Psychiat, Taipei 11217, Taiwan Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 , Div Psychiat, Taipei 112, Taiwan
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 2, volume: 44, anno: 2001,
pagine: 95 - 98
SICI:
0302-282X(2001)44:2<95:ABTSPO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-3 RECEPTOR; MSCI POLYMORPHISM; SUSCEPTIBILITY; DISORDERS; VARIANT; CYP2D6;
Keywords:
antipsychotics; dopamine D3 receptor; genetic association; genetic polymorphism; tardive dyskinesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, SJ Vet Gen Hosp, Dept Psychiat, 201,Shih Pai Rd,Sec 2, Taipei 11217,Taiwan Vet Gen Hosp 201,Shih Pai Rd,Sec 2 Taipei Taiwan 11217 7, Taiwan
Citazione:
D.L. Liao et al., "Association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients", NEUROPSYCHB, 44(2), 2001, pp. 95-98

Abstract

It has been suggested that dopamine D3 receptor (DRD3) may have important implications for antipsychotic-induced tardive dyskinesia (TD). Previous studies have demonstrated an association between a serine to glycine polymorphism in the first exon of the DRD3 gene and TD; however, the results have been inconsistent. Therefore, we have replicated these studies using a Chinese sample population. A total of 115 schizophrenic patients from chronic wards were assessed for TD severity using the Abnormal Involuntary Movements Scale (AIMS) and were subsequently genotyped for the DRD3 polymorphism. Themean AIMS score for patients carrying the heterozygote (DRD3(ser-gly)) wassignificantly greater than for those with the homozygotes (DRD3(ser-ser) and DRD3(gly-gly)). Our results are in line with a previous report, the results of which suggest that the presence of the DRD3(ser-gly) genotype may bea risk factor for the development of TD in patients treated with antipsychotics. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 01/04/20 alle ore 02:02:24