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Titolo:
Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans
Autore:
Spitzer, M; Franke, B; Walter, H; Buechler, J; Wunderlich, AP; Schwab, M; Kovar, KA; Hermle, L; Gron, G;
Indirizzi:
Univ Ulm, Dept Psychiat, D-89075 Ulm, Germany Univ Ulm Ulm Germany D-89075 iv Ulm, Dept Psychiat, D-89075 Ulm, Germany Univ Tuebingen, Inst Pharmaceut, Tubingen, Germany Univ Tuebingen Tubingen Germany gen, Inst Pharmaceut, Tubingen, Germany Univ Ulm, Dept Radiol, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069Univ Ulm, Dept Radiol, D-89069 Ulm, Germany Dr Margarete Fischer Bosch Inst Clin Pharmacol, Inst Clin Pharmacol, D-7000 Stuttgart, Germany Dr Margarete Fischer Bosch Inst Clin Pharmacol Stuttgart Germany D-7000 Psychiat Hosp Christophsbad, Goeppingen, Germany Psychiat Hosp Christophsbad Goeppingen Germany bad, Goeppingen, Germany
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 2, volume: 41, anno: 2001,
pagine: 263 - 271
SICI:
0028-3908(200108)41:2<263:ECABAE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
(ECSTASY)-INDUCED SEROTONIN NEUROTOXICITY; 3,4-METHYLENEDIOXYETHYLAMPHETAMINE MDE; MEMORY DEFICITS; HEALTHY-VOLUNTEERS; D-METHAMPHETAMINE; ECSTASY MDMA; DOUBLE-BLIND; RAT-BRAIN; USERS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE;
Keywords:
(S)-MDE; (R-)MDE; functional imaging; neuropsychology; neurotoxicity; MDMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Spitzer, M Univ Ulm, Dept Psychiat, Leimgrubenweg 12-14, D-89075 Ulm, Germany Univ Ulm Leimgrubenweg 12-14 Ulm Germany D-89075 Ulm, Germany
Citazione:
M. Spitzer et al., "Enantio-selective cognitive and brain activation effects of N-ethyl-3,4-methylenedioxyamphetamine in humans", NEUROPHARM, 41(2), 2001, pp. 263-271

Abstract

In a randomised double-blind trial the subjective, neuropsychological and brain activation effects of the two enantiomers of the MDMA (ecstasy-) likedrug N-ethyl-3,4-methylenedioxyamphetamine (NIDE) were studied in five normal subjects using functional magnetic resonance imaging (fMRI). (S)-MDE produced elevated mood, impairments in conceptually driven cognition and marked right frontal activation. In contrast, (R)-MDE produced increased depression, enhanced visual feature processing, and activation of visual corticaland left frontal areas. Plasma concentrations were higher for the (R)-enantiomer. The so-called entactogenic effects of MDE are likely to be caused by the (S)-enantiomer, whereas (R)-MDE appears to be responsible for neurotoxic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:57:21