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Titolo:
EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection
Autore:
Melis, MR; Succu, S; Spano, MS; Deghenghi, R; Argiolas, A;
Indirizzi:
Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 t Neurosci, I-09124 Cagliari, Italy Europeptides, Argenteuil, France Europeptides Argenteuil FranceEuropeptides, Argenteuil, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 2, volume: 41, anno: 2001,
pagine: 254 - 262
SICI:
0028-3908(200108)41:2<254:E9PE8P>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; NITRIC-OXIDE PRODUCTION; PARAVENTRICULAR NUCLEUS; MALE-RATS; SECRETAGOGUE RECEPTOR; HEXARELIN ANALOGS; OMEGA-CONOTOXIN; HYPOTHALAMUS; PITUITARY; NEUROPEPTIDES;
Keywords:
penile erection; EP peptides; hexarelin analogues; nitric oxide (NO); paraventricular nucleus of the hypothalamus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Argiolas, A Univ Cagliari, Bb Brodie Dept Neurosci, Via Porcell 4, I-09124Cagliari, Italy Univ Cagliari Via Porcell 4 Cagliari Italy I-09124 ari, Italy
Citazione:
M.R. Melis et al., "EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection", NEUROPHARM, 41(2), 2001, pp. 254-262

Abstract

The effect of EP 91073, EP 51389, EP 70555 and EP 51216, peptide analoguesof the growth hormone releasing peptide hexarelin, on penile erection induced by EP 80661 or EP 60761 injected into the paraventricular nucleus of the hypothalamus, was studied in male rats. Of the above peptides only EP 91073 (0.2-1 mug) was found capable of reducing penile erection induced by EP 80661 or EP 60761, when given into the paraventricular nucleus. Despite itsability to prevent EP peptide-induced penile erection, EP 91073 (1 mug) was unable to prevent penile erection induced by the dopamine receptor agonist apomorphine (50 ng), oxytocin (30 ng) and N-methyl-D-aspartic acid (50 ng), when given into the paraventricular nucleus 10 min prior to the above substances. The EP 91073-induced prevention of penile erection occurred with a reduction in the increase in nitric oxide production that occurs in the paraventricular nucleus concomitant to penile erection induced by EP 80661 and EP 60761, as measured by intracerebral vertical microdialysis. The present results are in line with the hypothesis that EP 80661 and EP 60761 induce penile erection by activating specific receptors in the paraventricular nucleus, located possibly in oxytocinergic neurons mediating penile erection, and show that EP 91073 acts as an antagonist of these EP peptide receptors mediating penile erection. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:13:04