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Titolo:
Long-term treatment with antidepressant drugs reduces the sensitivity of cortical cholinergic neurons to the activating actions of stress and the anxiogenic drug FG 7142
Autore:
Dazzi, L; Vacca, G; Ladu, S; Pisu, MG; Serra, M; Biggio, G;
Indirizzi:
Univ Cagliari, Dept Expt Biol B Loddo, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 ol B Loddo, I-09123 Cagliari, Italy Univ Cagliari, CNR, Ctr Neuropharmacol, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 opharmacol, I-09123 Cagliari, Italy
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 2, volume: 41, anno: 2001,
pagine: 229 - 237
SICI:
0028-3908(200108)41:2<229:LTWADR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS NEURONS; ACETYLCHOLINE-RELEASE; RAT-BRAIN; RECEPTOR; MODULATION; ANXIETY; CORTEX; MIRTAZAPINE; DOPAMINE; MICRODIALYSIS;
Keywords:
antidepressant drug; acetylcholine; prefrontal cortex; microdialysis; stress; FG 7142;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Dazzi, L Univ Cagliari, Dept Expt Biol B Loddo, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 o, I-09123 Cagliari, Italy
Citazione:
L. Dazzi et al., "Long-term treatment with antidepressant drugs reduces the sensitivity of cortical cholinergic neurons to the activating actions of stress and the anxiogenic drug FG 7142", NEUROPHARM, 41(2), 2001, pp. 229-237

Abstract

Certain antidepressant drugs exert an anxiolytic action in both humans androdents. The effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with different mechanisms of action, on the response of cortical cholinergic neurons to foot-shock stress or to the anxiogenic drug FG 7142 were investigated in freely moving rats. Chronic treatmentwith imipramine or mirtazapine reduced the increase in cortical acetylcholine output induced by foot-shock stress by similar to 50%. The same treatment also reduced the sensitivity of cortical cholinergic neurons to the stimulatory effect of acute administration of FG 7142. In contrast, the administration of a single dose of either antidepressant 40 min before foot shock or FG 7142 injection failed to increase the threshold of excitability of cortical cholinergic neurons. These results demonstrate that long-term treatment with either imipramine or mirtazapine reduces the sensitivity of cortical cholinergic neurons to stress or to an anxiogenic drug with an efficacy similar to that of acute administration of benzodiazepines. The neurochemical mechanism responsible for regulation of cholinergic neuron sensitivity might contribute to the modulation of cognitive function associated with emotional and affective disorders. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:42:52