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Titolo:
Modulation of the levels of NMDA receptor subunit mRNA and the bindings of[H-3]MK-801 in rat brain by chronic infusion of subtoxic dose of MK-801
Autore:
Oh, S; Kim, YH; Hann, HJ; Lee, HL; Choi, HS; Kim, HS; Ho, IK;
Indirizzi:
Ewha Womans Univ, Coll Med, Med Res Ctr, Dept Neurosci,Yangchon Ku, Seoul 158710, South Korea Ewha Womans Univ Seoul South Korea 158710 Ku, Seoul 158710, South Korea Ewha Womans Univ, Coll Med, Dept Anat, Seoul 158710, South Korea Ewha Womans Univ Seoul South Korea 158710 nat, Seoul 158710, South Korea
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 5, volume: 26, anno: 2001,
pagine: 559 - 565
SICI:
0364-3190(200105)26:5<559:MOTLON>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; STATUS EPILEPTICUS; EXPRESSION; ANTAGONIST; DOPAMINE; SCHIZOPHRENIA; PHENCYCLIDINE; GLUTAMATE; SUBTYPES; EFFICACY;
Keywords:
NMDA receptor; MK-801; in situ hybridization; autoradiography; osmotic pump;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Oh, S Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 361763, South Korea
Citazione:
S. Oh et al., "Modulation of the levels of NMDA receptor subunit mRNA and the bindings of[H-3]MK-801 in rat brain by chronic infusion of subtoxic dose of MK-801", NEUROCHEM R, 26(5), 2001, pp. 559-565

Abstract

The effects of continuous infusion of NMDA receptor antagonist MK-801 on the modulation of NMDA receptor subunits NR1, NR2A, NR2B, and NR2C were investigated by using in situ hybridization study. Differential assembly of NMDA receptor subunits determines their functional characteristics. Continuousintracerebroventricular (i.c.v.) infusion with MK-801 (1 pmol/ 10 mul/h) for 7 days resulted in significant modulations in the NR1, NR2A, and NR2B mRNA levels without producing stereotypic motor syndromes. The levels of NR1 mRNA were significantly increased (9-20%) in the cerebral cortex, striatum,septum, and CAI of hippocampus in MK-801-infused rats. The levels of NR2A mRNA were significantly decreased (11-16%) in the CA3 and dentate gyrus of hippocampus in MK-801-infused rats. In contrast to NR2A, NR2B subunit mRNA levels were increased (10-14%) in the cerebral cortex, caudate putamen, andthalamus. However, no changes of NR2C subunits in cerebellar granule layerwere observed. Using quantitative ligand autoradiography, the binding of NMDA receptor ligand [H-3]MK-801 was increased (12-25%) significantly in almost all brain regions except in the thalamus and cerebellum after 7 days infusion with MK-801. These results suggest that region-specific changes of NMDA receptor subunit mRNA and [3H]MK-801 binding are involved in the MK-801-infused adult rats.

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Documento generato il 23/01/20 alle ore 12:16:59