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Titolo:
Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain
Autore:
Rao, VLR; Bowen, KK; Dempsey, RJ;
Indirizzi:
Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 pt Neurol Surg, Madison, WI 53792 USA Univ Wisconsin, Cardiovasc Res Ctr, Madison, WI USA Univ Wisconsin Madison WI USA onsin, Cardiovasc Res Ctr, Madison, WI USA William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA William S Middleton Mem Vet Adm Med Ctr Madison WI USA , Madison, WI USA
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 5, volume: 26, anno: 2001,
pagine: 497 - 502
SICI:
0364-3190(200105)26:5<497:TFCIDG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY OCCLUSION; NEURONAL DEATH; CELL-DEATH; INJURY; GLAST; HIPPOCAMPUS; METABOLISM; RELEASE; MICE;
Keywords:
EAAC1; focal cerebral ischemia; gene expressions; GLT-1; glutamate transporters; stroke;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, VLR Univ Wisconsin, Dept Neurol Surg, F4-309 CSC,600 Highland Ave, Madison, WI53792 USA Univ Wisconsin F4-309 CSC,600 Highland Ave Madison WI USA 53792 A
Citazione:
V.L.R. Rao et al., "Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain", NEUROCHEM R, 26(5), 2001, pp. 497-502

Abstract

Transient focal cerebral ischemia leads to extensive excitotoxic neuronal damage in rat cerebral cortex. Efficient reuptake of the released glutamateis essential for preventing glutamate receptor over-stimulation and neuronal death. Present study evaluated the expression of the glial (GLT-1 and GLAST) and neuronal (EAAC1) subtypes of glutamate transporters after transient middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia in rats. Between 24h to 72h of reperfusion after transient MCAO, GLT-1 and EAAC1 protein levels decreased significantly (by 36% to 56%, p < 0.05) in the ipsilateral cortex compared with the contralateral cortex or sham control. GLT-1 and EAAC1 mRNA expression also decreased in the ipsilateral cortex of ischemic rats at both 24h and 72h of reperfusion, compared with the contralateral cortex or sham control. Glutamate transporter down-regulation maydisrupt the normal clearance of the synaptically-released glutamate and may contribute to the ischemic neuronal death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:20:10