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Titolo:
Distribution and modulation of histamine H-3 receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease
Autore:
Anichtchik, OV; Peitsaro, N; Rinne, JO; Kalimo, H; Panula, P;
Indirizzi:
Abo Akad Univ, Dept Biol, Turku 20520, Finland Abo Akad Univ Turku Finland 20520 Univ, Dept Biol, Turku 20520, Finland Turku Univ Hosp, Dept Pathol, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 Pathol, FIN-20520 Turku, Finland Turku Univ Hosp, Turku PET Ctr, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 ET Ctr, FIN-20520 Turku, Finland Huddinge Hosp, Karolinska Inst, Div Geriatr Med, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 iatr Med, S-14186 Huddinge, Sweden Univ Helsinki, Inst Biomed Anat, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 at, FIN-00014 Helsinki, Finland Turku Grad Sch Biomed Sci, Turku, Finland Turku Grad Sch Biomed Sci Turku Finland Sch Biomed Sci, Turku, Finland
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 707 - 716
SICI:
0969-9961(200108)8:4<707:DAMOHH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO AUTORADIOGRAPHY; SUBSTANTIA-NIGRA; HUMAN-BRAIN; RAT-BRAIN; 6-HYDROXYDOPAMINE-LESIONED RATS; DOPAMINERGIC-NEURONS; MEDIATED INHIBITION; ALZHEIMERS-DISEASE; HUNTINGTONS-CHOREA; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Anichtchik, OV Abo Akad Univ, Dept Biol, Turku 20520, Finland Abo Akad Univ Turku Finland 20520 l, Turku 20520, Finland
Citazione:
O.V. Anichtchik et al., "Distribution and modulation of histamine H-3 receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease", NEUROBIOL D, 8(4), 2001, pp. 707-716

Abstract

Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic systemappears to be activated in PD, since the histaminergic innervation is increased in the substantia nigra. The aim of the present study was to investigate the expression and function of histamine H-3 receptors in PD, using receptor mRNA in situ hybridization with oligonucleotide probes, receptor binding assay with a specific radioactive agonist, and GTP-gamma-[S-35]-bindingassay as a tool to study the activation of the receptor G-protein. H-3 receptor binding sites were detected using N-alpha -methylhistamine autoradiography in the basal ganglia and cortex, being most abundant in the substantia nigra and striatum. In PD substantia nigra we detected an increase of thereceptor binding density. In situ hybridization study of the receptor mRNArevealed prominent sites of H-3 receptor synthesis in the putamen, cortex,and globus pallidus, whereas very low mRNA expression was seen in the substantia nigra. In the PD pallidum externum, H-3 receptor mRNA expression waselevated as compared with the normal brains. GTP-gamma-[S-35]-binding assay did not reveal any significant difference between PD and normal brains, although the density values in PD substantia nigra tended to be lower than in the normal brain, and density values in PD striatum were higher. The dopaminergic neurons did not express significant amount of H-3 receptor mRNA, suggesting that the effects of H-3 receptor-mediated modulation of dopamine release are indirect. Our data indicates modulation of the histamine H-3 receptor in PD at the level of the mRNA expression in the striatum and receptor density in the substantia nigra. The receptor activity seems to be unchanged or decreased, as revealed by GTP-gamma-[S-35]-binding assay. Modulation of the histamine H-3 receptor may influence the activity of other neurotransmitter systems, e.g., the GABAergic one, in the substantia nigra. (C) 2001 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:45:26