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Titolo:
Decreased MK-801 binding in discrete hippocampal regions of prion-infectedmice
Autore:
Diez, M; DeArmond, SJ; Groth, D; Prusiner, SB; Hokfelt, T;
Indirizzi:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 692 - 699
SICI:
0969-9961(200108)8:4<692:DMBIDH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB DISEASE; NEUROPEPTIDE-Y; SCRAPIE PRIONS; ANTICONVULSANT MK-801; TYROSINE-HYDROXYLASE; NIGROSTRIATAL SYSTEM; RECEPTOR ANTAGONISTS; GOLDEN-HAMSTER; MESSENGER-RNA; RAT-BRAIN;
Keywords:
autoradiography; glutamate; hippocampus; neurodegeneration; N-methyl-D-aspartate (NMDA); scrapie; binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Diez, M Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 17177 Stockholm, Sweden
Citazione:
M. Diez et al., "Decreased MK-801 binding in discrete hippocampal regions of prion-infectedmice", NEUROBIOL D, 8(4), 2001, pp. 692-699

Abstract

The neurochemical alterations associated with neurodegeneration in prion diseases are not well defined. It is therefore of interest to study the influence of prion infection on messenger molecules and their receptors. In thepresent study we have analyzed the possible involvement of NMDA receptors in prion-infected mice using ligand binding autoradiography and iodinated MK-801, a noncompetitive NMDA antagonist. The results show a reduced bindingof MK-801 in discrete regions of hippocampus at 110 days after infection, that is before the appearance of behavioral symptoms. In addition, early transient increases in MK-801 binding were observed in several layers. The exact neuroanatomical correlate of these changes in MK-801 binding, as well as its functional significance in relation to prion symptomatology, remain to be analyzed. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:54:25