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Titolo:
Involvement of GDNF in neuronal protection against 6-OHDA-induced parkinsonism following intracerebral transplantation of fetal kidney tissues in adult rats
Autore:
Borlongan, CV; Zhou, FC; Hayashi, T; Su, TP; Hoffer, BJ; Wang, Y;
Indirizzi:
NIDA, Cellular Neurobiol Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ral Res Program, NIH, Baltimore, MD 21224 USA Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 l Biol, Indianapolis, IN 46202 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 636 - 646
SICI:
0969-9961(200108)8:4<636:IOGINP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN DOPAMINERGIC-NEURONS; VENTRAL MESENCEPHALIC GRAFTS; NEUROTROPHIC FACTOR GDNF; FUNCTIONAL RECOVERY; ROTATIONAL BEHAVIOR; SUBSTANTIA-NIGRA; 6-HYDROXYDOPAMINE-INDUCED HEMIPARKINSONISM; STRIATAL DOPAMINE; FIBER OUTGROWTH; NERVOUS-SYSTEM;
Keywords:
Parkinson's disease; neural transplantation; dopamine; glial cell line-derived neurotrophic factor; substantia nigra; striatum; motor asymmetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Borlongan, CV NIDA, Cellular Neurobiol Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 m, NIH, Baltimore, MD 21224 USA
Citazione:
C.V. Borlongan et al., "Involvement of GDNF in neuronal protection against 6-OHDA-induced parkinsonism following intracerebral transplantation of fetal kidney tissues in adult rats", NEUROBIOL D, 8(4), 2001, pp. 636-646

Abstract

Exogenous application of transforming growth factors-beta (TGF beta) family proteins, including glial cell line-derived neurotrophic factor (GDNF), neurturin, activin, and bone morphogenetic proteins, has been shown to protect neurons in many models of neurological disorders. Finding a tissue source containing a variety of these proteins may promote optimal beneficial effects for treatment of neurodegenerative diseases. Because fetal kidneys express many TGF beta trophic factors, we transplanted these tissues directly into the substantial nigra after a unilateral 6-hydroxydopamine lesion. We found that animals that received fetal kidney tissue grafts exhibited (1) significantly reduced hemiparkinsonian asymmetrical behaviors, (2) a near normal tyrosine hydroxylase immunoreactivity in the lesioned nigra and striatum, (3) a preservation of K+-induced dopamine release in the lesioned striatum, and (4) high levels of GDNF protein within the grafts. In contrast, lesioned animals that received grafts of adult kidney tissues displayed significant behavioral deficits, dopaminergic depletion, reduced K+-mediated striatal dopamine release, and low levels of GDNF protein within the grafts. The present study suggests that fetal kidney tissue grafts can protect the nigrostriatal dopaminergic system against a neurotoxin-induced parkinsonism,possibly through the synergistic release of GDNF and several other neurotrophic factors. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:41:19