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Titolo:
Renal disease in type 2 diabetes
Autore:
Ritz, E; Tarng, DC;
Indirizzi:
Univ Heidelberg, Dept Internal Med, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Natl Yang Ming Univ, Taichung Vet Gen Hosp, Taipei, Taiwan Natl Yang Ming Univ Taipei Taiwan Taichung Vet Gen Hosp, Taipei, Taiwan
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 5
pagine: 11 - 18
SICI:
0931-0509(2001)16:<11:RDIT2D>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIMA-INDIANS; BLOOD-PRESSURE; NEPHROPATHY; MELLITUS; PROGRESSION; HYPERTENSION; KIDNEY; ONSET; PROTEINURIA; ENALAPRIL;
Keywords:
diabetic glomerulopathy; dialysis; endstage renal failure; hypertension; microalbuminuria; proteinuria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ritz, E Univ Heidelberg, Dept Internal Med, Bergheimer Str 58, D-69115 Heidelberg,Germany Univ Heidelberg Bergheimer Str 58 Heidelberg Germany D-69115 many
Citazione:
E. Ritz e D.C. Tarng, "Renal disease in type 2 diabetes", NEPH DIAL T, 16, 2001, pp. 11-18

Abstract

The prevalence of type 2 diabetes is rising in all Westernized societies. Presumably as a consequence of diminishing cardiovascular mortality, end-stage renal failure (ESRF) in patients with diabetes (mostly type 2) as a co-morbid condition has risen dramatically in the past decade. This constellation has become the single most common cause of ESRF in most countries. Suchan epidemiological trend is particularly regrettable, since in uraemic diabetic patients, medical rehabilitation and survival are remarkably poor. Recent studies indicate that an interplay between genetic predisposition and factors, some of them susceptible to intervention, such as hyperglycaemia, blood pressure, smoking, age, gender and ethnicity, predispose to the development and progression of nephropathy. It has also become clear that trace albuminuria ('micro-albuminuria') provides unique opportunities to recognize incipient renal involvement early on, although it is less specific in type 2 as compared with type 1 diabetes. Factors that promote progression include hypertension, proteinuria, smoking, glycaemic control and, less certainly, dietary protein intake and hyperlipidaemia. Cumulating evidence indicates that early intervention delays progression of nephropathy. The most important strategies to combat the medical catastrophe of increasing numbers ofdiabetic patients with ESRF include: (i) prevention of diabetes (mainly type 2): (ii) glycaemic control to prevent onset of renal involvement and (iii) meticulous antihypertensive treatment to avoid progression of nephropathy.

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Documento generato il 07/07/20 alle ore 22:09:45