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Titolo:
The role of macrophages in glomerulonephritis
Autore:
Nikolic-Paterson, DJ; Atkins, RC;
Indirizzi:
Monash Univ, Monash Med Ctr, Dept Nephrol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 hrol, Clayton, Vic 3168, Australia Monash Univ, Monash Med Ctr, Dept Med, Clayton, Vic 3168, Australia MonashUniv Clayton Vic Australia 3168 Med, Clayton, Vic 3168, Australia
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 5
pagine: 3 - 7
SICI:
0931-0509(2001)16:<3:TROMIG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MIGRATION INHIBITORY FACTOR; NEPHROTOXIC SERUM NEPHRITIS; GLOMERULAR INJURY; ENGINEERED MACROPHAGES; LUPUS NEPHRITIS; KIDNEY-DISEASE; RAT;
Keywords:
adhesion molecules; cytokines; glomerulonephritis; macrophages; M-CSF tubules;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Atkins, RC Monash Univ, Monash Med Ctr, Dept Nephrol, Clayton Rd, Clayton,Vic 3168, Australia Monash Univ Clayton Rd Clayton Vic Australia 3168 68, Australia
Citazione:
D.J. Nikolic-Paterson e R.C. Atkins, "The role of macrophages in glomerulonephritis", NEPH DIAL T, 16, 2001, pp. 3-7

Abstract

Macrophage accumulation is a prominent feature in most types of human glomerulonephritis. In particular, tubulointerstitial macrophage accumulation correlates with the degree of renal dysfunction and is predictive of diseaseprogression. Depletion studies have shown that macrophages can induce glomerular injury in experimental glomerulonephritis. Moreover, recent studies targeting chemokines and adhesion molecules have shown that inhibiting macrophage accumulation can suppress progressive renal injury in animal models of glomerulonephritis. Macrophages can produce many molecules with the potential to cause renal damage, although the precise mechanism(s) of macrophage-mediated renal injury have yet to be determined. It is now evident that tubules-a major source of chemokines and adhesion molecules-play an active role in promoting interstitial macrophage infiltration and activation. Thus,targeting pro-inflammatory functions of tubular epithelial cells may be aneffective means to inhibit macro phage-mediated tubulointerstitial injury without causing systemic immunosuppression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:32:21