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Titolo:
Biomarkers of genotoxicity of urban air pollution - Overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons: the AULIS project
Autore:
Kyrtopoulos, SA; Georgiadis, P; Autrup, H; Demopoulos, N; Farmer, P; Haugen, A; Katsouyanni, K; Lambert, B; Ovrebo, S; Sram, R; Stefanou, GS; Topinka, J;
Indirizzi:
Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Athens 11635, Greece NatlHellen Res Fdn Athens Greece 11635 Biotechnol, Athens 11635, Greece Univ Aarhus, Aarhus, Denmark Univ Aarhus Aarhus DenmarkUniv Aarhus, Aarhus, Denmark Univ Patras, Dept Biol, Patras, Greece Univ Patras Patras GreeceUniv Patras, Dept Biol, Patras, Greece MRC, Toxicol Unit, Leicester, Leics, England MRC Leicester Leics EnglandMRC, Toxicol Unit, Leicester, Leics, England Inst Occupat Hlth, Oslo, Norway Inst Occupat Hlth Oslo NorwayInst Occupat Hlth, Oslo, Norway Univ Athens, Dept Hyg Epidemiol, Athens, Greece Univ Athens Athens Greece iv Athens, Dept Hyg Epidemiol, Athens, Greece Karolinska Inst, Stockholm, Sweden Karolinska Inst Stockholm SwedenKarolinska Inst, Stockholm, Sweden Acad Med Sci Czech Republ, Lab Genet Ecotoxicol, Prague, Czech Republic Acad Med Sci Czech Republ Prague Czech Republic Prague, Czech Republic
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 496, anno: 2001,
pagine: 207 - 228
SICI:
1383-5718(20010920)496:1-2<207:BOGOUA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGE; COKE-OVEN WORKERS; DNA ADDUCT LEVELS; HPRT MUTANT FREQUENCY; NAT2 GENOTYPES; LUNG-CANCER; CHROMOSOMAL-ABERRATIONS; GSTM1 GENOTYPE; GENETIC-DAMAGE; HUMAN PLACENTA;
Keywords:
bulky DNA adducts; HPRT mutations; sister-chromatid exchanges; chromosome aberrations; P-32-postlabelling; benzene; PM2.5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kyrtopoulos, SA Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, 48 Vassileos ConstantinouAve, Athens 11635, Greece Natl Hellen Res Fdn 48 Vassileos Constantinou Ave Athens Greece 11635
Citazione:
S.A. Kyrtopoulos et al., "Biomarkers of genotoxicity of urban air pollution - Overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons: the AULIS project", MUT RES-GTE, 496(1-2), 2001, pp. 207-228

Abstract

Epidemiologic studies indicate that prolonged exposure to high pollution levels is associated with increased risk of cancer, especially lung cancer. However, under conditions of moderate or low air pollution, epidemiologic evidence does not permit reliable conclusions. Biomarker-based population studies may serve as complementary tools providing a better understanding of the relative contribution of ambient atmospheric pollution to the overall genotoxic burden suffered by city dwellers. However, past efforts to apply biomarkers to studies of low levels exposure to urban air pollution have given inconclusive results, partly because of the absence of adequate data on personal exposure, covering a time-window which is appropriate for the biomarkers being examined, as well as a battery of biomarkers reflecting different stages of the carcinogenic process. In the present paper, the potential of biomarker-based population studies to aid the assessment of the genotoxic and carcinogenic effects of urban air pollution is reviewed by reference to the achievements and limitations ofearlier reported studies. The design and methodology adopted in a recentlycompleted large-scale population study, carried out in the context of the European Union Environment and Climate Programme, known by the short name of AULIS project,(1) is discussed and descriptive statistics of the main findings of the project are presented. These findings indicate that for cohorts suffering moderate-to-low exposures to airborne particulate-bound polycyclic aromatic hydrocarbons (PAHs), no simple correlation with biomarkers of genotoxicity existed and suggest that additional factors made a significantcontribution to the overall genotoxic burden. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 27/09/20 alle ore 06:58:00