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Titolo:
Expression of interleukin-6, interleukin-6 receptor (gp80), and the receptor's signal-transducing subunit (gp130) in human normal pituitary glands and pituitary adenomas
Autore:
Kurotani, R; Yasuda, M; Oyama, K; Egashira, N; Sugaya, M; Teramoto, A; Osamura, RY;
Indirizzi:
Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Nippon Med Coll, Dept Neurosurg, Tokyo 113, Japan Nippon Med Coll Tokyo Japan 113 d Coll, Dept Neurosurg, Tokyo 113, Japan
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 8, volume: 14, anno: 2001,
pagine: 791 - 797
SICI:
0893-3952(200108)14:8<791:EOIIR(>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICULO-STELLATE CELLS; IN-VIVO; IL-6; RELEASE; INVITRO; RAT;
Keywords:
gp80; gp130; human pituitary adenoma; human pituitary gland; IL-6; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Osamura, RY Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 gawa 2591193, Japan
Citazione:
R. Kurotani et al., "Expression of interleukin-6, interleukin-6 receptor (gp80), and the receptor's signal-transducing subunit (gp130) in human normal pituitary glands and pituitary adenomas", MOD PATHOL, 14(8), 2001, pp. 791-797

Abstract

Interleukin-6 (IL-6) is an important cytokine in cen proliferation and differentiation in several organs. It has also been reported that IL-6 plays arole in secretion or release of pituitary hormones in pituitary hormone-secreting cells and pituitary adenomas, but convincing data in situ have not yet been reported. In this study, we examined the participation of IL-6 in the production of pituitary hormones and the differences between human normal pituitary glands and pituitary adenomas by determination of the localization or expression of IL-6, IL-6 receptor (IL-6R, gp80), and the signal-transducing subunit (gp130) of the receptor using immunohistochemical stainingand RT-PCR. IL-6 was mainly expressed in ACTH- and FSH/LH-secreting cells in normal pituitary glands, as shown by double staining. gp 80 and gp130 were coexpressed in almost all GH- and PRL-secreting cells and in approximately 30% of FSH/LH-secreting cells. RT-PCR showed that IL-6 mRNA was expressed in only one of all the pituitary adenomas examined, whereas gp 80 and gp 130 mRNAs were detected in all these pituitary adenomas. In conclusion, IL-6 was mainly expressed in ACTH- and FSH/LH-secreting cells, and the receptors were expressed in GH-, PRL- and FSH/LH-secreting cells in human normal pituitary glands. Furthermore, our data emphasized that the mechanism of IL-6 function in human pituitary adenoma cells is distinct from that in normalpituitary cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:55:45