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Titolo:
The morphology, immunophenotype and distribution of paracortical dendriticleucocytes in lymph nodes regional to cutaneous melanoma
Autore:
Lana, AMA; Wen, DR; Cochran, AJ;
Indirizzi:
Univ Calif Los Angeles, Ctr Hlth Sci, Jonsson Comprehens Canc Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Hlth Sci, Jonsson Comprehens Canc Ctr, Dept Surg, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Fed Minas Gerais, Fac Med, Dept Anat Patol, Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil elo Horizonte, MG, Brazil
Titolo Testata:
MELANOMA RESEARCH
fascicolo: 4, volume: 11, anno: 2001,
pagine: 401 - 410
SICI:
0960-8931(200108)11:4<401:TMIADO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; TYROSINASE MESSENGER-RNA; INTERDIGITATING CELLS; MONOCLONAL-ANTIBODY; MALIGNANT-MELANOMA; S-100 PROTEIN; T-CELL; HISTOLOGY; SECTIONS; SUBSETS;
Keywords:
antigen-presenting cells; dendritic leucocytes; immunocytochemistry; lymph nodes; melanoma; morphology and immunophenotype of dendritic cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Cochran, AJ Univ Calif Los Angeles, Ctr Hlth Sci, Jonsson Comprehens Canc Ctr, Dept Pathol & Lab Med, Box 951732, Los Angeles, CA 90095 USA Univ Calif Los Angeles Box 951732 Los Angeles CA USA 90095 USA
Citazione:
A.M.A. Lana et al., "The morphology, immunophenotype and distribution of paracortical dendriticleucocytes in lymph nodes regional to cutaneous melanoma", MELANOMA RE, 11(4), 2001, pp. 401-410

Abstract

Our aim was to identify and delineate alterations in the distribution and immunophenotype of the lymphocytes and paracortical dendritic leucocytes (interdigitating dendritic cells; IDCs) in lymph nodes regional to tumours. Using immunocytochemistry and computer-assisted image analysis we examined 65 lymph nodes excised from 47 patients with malignant melanoma. Twenty-ninepatients had American Joint Committee on Cancer (AJCC) stage II melanoma (no tumour spread beyond the primary site) and 18 had AJCC stage III disease(metastases in the regional nodes). There were significant differences in the frequency, morphology, immunophenotype and anatomical distribution of the IDCs and in the complexity of their dendritic processes in different areas within individual lymph nodes. We conclude that morphological and phenotypical variations in IDCs correlate with differing levels of antigen presentation. Downregulation of antigen presentation in lymph nodes regional to tumours is most probably mediated by tumour products. Differences In IDC distribution and characteristics in lymph nodes from different anatomical sites must be considered in interpreting studies of nodal morphology and function. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:32:21