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Titolo:
Melanoma induction in a hairless mouse with short-term application of dimethylbenz[a]anthracene
Autore:
Kligman, LH; Elenitsas, R;
Indirizzi:
Univ Penn, Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dermatol, Philadelphia, PA 19104 USA
Titolo Testata:
MELANOMA RESEARCH
fascicolo: 4, volume: 11, anno: 2001,
pagine: 319 - 324
SICI:
0960-8931(200108)11:4<319:MIIAHM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MALIGNANT-MELANOMA; ULTRAVIOLET-RADIATION; SKIN MELANOMA; GUINEA-PIGS; MICE; EXPOSURE;
Keywords:
chemical carcinogens; melanoma; metastases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kligman, LH Univ Penn, Sch Med, Dept Dermatol, 202 Clin Res Bldg,415 CurieBlvd, Philadelphia, PA 19104 USA Univ Penn 202 Clin Res Bldg,415 Curie Blvd Philadelphia PA USA 19104
Citazione:
L.H. Kligman e R. Elenitsas, "Melanoma induction in a hairless mouse with short-term application of dimethylbenz[a]anthracene", MELANOMA RE, 11(4), 2001, pp. 319-324

Abstract

Melanomas have been induced in hamsters and guinea pigs with short-term, low dose applications of dimethylbenz [a]anthracene (DMBA) alone. In mice, however, melanoma induction has required either croton oil or ultraviolet radiation promotion in addition to DMBA. In this study, we report the development of a malignant melanoma, with metastases, in a hairless mouse after six applications of 0.25% DMBA alone. At sacrifice, a large primary tumour with characteristics of intralesional transformation was present, along with numerous pigmented macules and papules. Metastases were present in lymph nodes and lungs. There was a marked similarity between this melanoma and its precursor lesions and those seen in an earlier, Weiser-Maple guinea pig model, which, in turn, resembled human melanoma. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/11/20 alle ore 18:40:57