Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Poor prognosis acute myelogenous leukemia: 3-biological and molecular biological changes during remission induction therapy
Autore:
Devemy, E; Li, B; Tao, M; Horvath, E; Chopra, H; Fisher, L; Nayini, J; Creech, S; Venugopal, P; Yang, J; Kaspar, C; Hsu, WT; Preisler, HD;
Indirizzi:
Rush Canc Inst, Chicago, IL 60612 USA Rush Canc Inst Chicago IL USA 60612Rush Canc Inst, Chicago, IL 60612 USA
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 9, volume: 25, anno: 2001,
pagine: 783 - 791
SICI:
0145-2126(200109)25:9<783:PPAML3>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; MYELODYSPLASTIC SYNDROMES; TREATMENT FAILURE; CELLS; APOPTOSIS; EXPRESSION; MUTATIONS; AML;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Preisler, HD Rush Canc Inst, 1725 W Harrison St,Suite 809, Chicago, IL 60612 USA Rush Canc Inst 1725 W Harrison St,Suite 809 Chicago IL USA 60612
Citazione:
E. Devemy et al., "Poor prognosis acute myelogenous leukemia: 3-biological and molecular biological changes during remission induction therapy", LEUK RES, 25(9), 2001, pp. 783-791

Abstract

This is the third paper in a series which describes a new remission induction regimen for patients with 'poor prognosis acute myelogenous leukemia (AML). Twenty-four patients were treated with two one day pulses of chemotherapy separated by 96 h. Each pulse consisted of two doses of cytarabine and a single dose of mitoxantrone. Amifostine was administered three times a week after the second pulse of chemotherapy until treatment outcome became known. The first paper described the outcome of treatment while the second described the relationship of treatment outcome to the pretherapy characteristics of the leukemia. This paper describes the changes in the leukemia cells which occur during remission induction therapy. While only a limited number of specimens were available for each post treatment study, the studies demonstrated a profound fall in blood counts, BM cellularity, and telomeraseactivity in leukemia cells after pulse # I of treatment. This fall was usually accompanied by a coordinate rise in IL6, TNF alpha. and IL1 beta transcripts within the AML cells which survived chemotherapy. High levels of telomerase activity in the day 5 marrow was correlated with high levels of IL1beta transcripts which in turn were associated with treatment failure ascribable to resistant disease. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:02:53