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Titolo:
Effects of anastomotic angle on vascular tissue responses at end-to-side arterial grafts
Autore:
Jackson, ZS; Ishibashi, H; Gotlieb, AL; Langille, BL;
Indirizzi:
Toronto Gen Res Inst, Toronto, ON M5G 2C4, Canada Toronto Gen Res Inst Toronto ON Canada M5G 2C4 oronto, ON M5G 2C4, Canada Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada Univ Toronto Toronto ON Canada ept Lab Med & Pathol, Toronto, ON, Canada Univ Hlth Network, Dept Pathol, Toronto, ON, Canada Univ Hlth Network Toronto ON Canada rk, Dept Pathol, Toronto, ON, Canada
Titolo Testata:
JOURNAL OF VASCULAR SURGERY
fascicolo: 2, volume: 34, anno: 2001,
pagine: 300 - 307
SICI:
0741-5214(200108)34:2<300:EOAAOV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
WALL SHEAR-STRESS; FLOW VELOCITY PROFILES; BLOOD-FLOW; INTIMAL HYPERPLASIA; CAROTID BIFURCATION; IN-VIVO; SURVIVAL; INJURY; MODEL; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Langille, BL Toronto Gen Res Inst, 200 Elizabeth St,CCRW 1-836, Toronto, ON M5G 2C4, Canada Toronto Gen Res Inst 200 Elizabeth St,CCRW 1-836 Toronto ON Canada M5G 2C4
Citazione:
Z.S. Jackson et al., "Effects of anastomotic angle on vascular tissue responses at end-to-side arterial grafts", J VASC SURG, 34(2), 2001, pp. 300-307

Abstract

Objective: Hemodynamics has been implicated in the late failure of arterial bypass grafts, which frequently occurs at the distal anastomosis site. This study was designed to assess the relationship between local hemodynamicsand pathologic responses of the distal anastomosis by manipulation of the angle of anastomosis of the graft, a major determinant of local hemodynamics. Methods: End-to-side anastomoses of the right carotid to the left carotid arteries of rabbits were performed at anastomotic angles of less than 10 degrees (acute), 45 degrees (intermediate), or 90 degrees (right angle), and then the upstream left carotid arteries were ligated to simulate pathologicocclusion. We examined tissue responses on the wall of the recipient vessel opposite the anastomosis site (the bed), where unusual hemodynamic forcesare imposed. Results. Three months after surgery, intimal thickening was observed on the upstream portion of the acute, and more rarely, the intermediate anastomoses only. Medial thinning caused by loss of cells and matrix, and an aneurysm-like dilation, was observed in the right angle and some intermediate anastomoses, but not in the acute anastomoses. En face confocal microscopy at 3 weeks after surgery revealed severe disruption of the internal elastic lamina in all anastomotic models. Zymography and Western immunoblotting demonstrated gelatinolytic activity, caused by expression and activation of MMP-2, that was lowest in the acute anastomoses, higher in the intermediate anastomoses, and highest in the right-angle anastomoses. Conclusions: We infer that very different pathologic changes to the vesselwall are elicited when local hemodynamics is manipulated by altering the anastomotic branch angle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:23:08