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Titolo:
Evidence for the involvement of nitric oxide in the control of steroid secretion by the frog adrenal gland
Autore:
Cartier, F; Do-Rego, JL; Remy-Jouet, I; Fournier, A; Vaudry, H; Delarue, C;
Indirizzi:
Univ Rouen, European Inst Peptide Res IFRMP 23, Lab Cellular & Mol Neuroendocrinol, UA CNRS,INSERM,U413, F-76821 Mont St Aignan, France Univ Rouen Mont St Aignan France F-76821 F-76821 Mont St Aignan, France Univ Quebec, INRS, Inst Armand Frappier, Pointe Claire, PQ H9R 1G6, CanadaUniv Quebec Pointe Claire PQ Canada H9R 1G6 te Claire, PQ H9R 1G6, Canada
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 4-5, volume: 77, anno: 2001,
pagine: 251 - 259
SICI:
0960-0760(200106)77:4-5<251:EFTION>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL NATRIURETIC PEPTIDE; GENE-RELATED PEPTIDE; CORTICOSTEROID SECRETION; ADRENOCORTICAL-CELLS; CHROMAFFIN CELLS; BIOCHEMICAL-CHARACTERIZATION; ALDOSTERONE SECRETION; BIOLOGICAL-ACTIVITY; CYCLASE; LOCALIZATION;
Keywords:
nitric oxide; adrenocorticotropic hormone; angiotensin II; endothelin-1; corticosterone; aldosterone; adrenocortical cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Vaudry, H Univ Rouen, European Inst Peptide Res IFRMP 23, Lab Cellular & Mol Neuroendocrinol, UA CNRS,INSERM,U413, F-76821 Mont St Aignan, France Univ Rouen Mont St Aignan France F-76821 ont St Aignan, France
Citazione:
F. Cartier et al., "Evidence for the involvement of nitric oxide in the control of steroid secretion by the frog adrenal gland", J STEROID B, 77(4-5), 2001, pp. 251-259

Abstract

Nitric oxide (NO) has been found to modulate the response of rat, bovine and human adrenocortical cells to corticotropic factors. The aim of the present study was to investigate the possible involvement of NO in the control of corticosteroid secretion in the frog Rana ridibunda. Histochemical studies using the NADPH-diaphorase reaction and immunohistochemical labeling with antibodies against NO synthase (NOS) revealed that NOS is exclusively expressed in chromaffin cells. The NO donor sodium nitroprusside (SNP) and theNO synthase inhibitor Nw-nitro-L-arginine (L-NO,Arg) did not modify the spontaneous production of corticosterone and aldosterone by perifused adrenalslices. Similarly, L-NO(2)Arg had no effect on the secretory responses induced by ACTH, angiotensin II (AII) and endothelin-1 (ET-1). In contrast, SNP significantly inhibited the stimulatory effects of ACTH, AII and ET-1 on corticosterone and aldosterone secretion. These data provide the first evidence for a modulatory role of NO on adrenocortical cell activity in amphibians. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:08:37